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Spike protein

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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* Human virus spike protein
+
* Human virus spike protein; Domain Receptor Binding Domain (RBD) 318-510; HR1 910-1054; HR2 1162-1286
-
**[[5wrg]], [[5xlr]] – hscvSpi – human SARS-CoV – Cryo EM <br />
+
**[[5wrg]], [[5xlr]], [[6acc]], [[6acd]] – hscvSpi – human SARS-CoV – Cryo EM <br />
**[[6crv]], [[6crw]], [[6crx]], [[6crz]], [[6cs0]], [[6cs1]] – hscvSpi (mutant) – Cryo EM <br />
**[[6crv]], [[6crw]], [[6crx]], [[6crz]], [[6cs0]], [[6cs1]] – hscvSpi (mutant) – Cryo EM <br />
-
**[[1wnc]] – hscvSpi fusion core 900-1184<br />
+
**[[1wnc]] – hscvSpi HR1 motif <br />
-
**[[2ghv]] – hscvSpi RBD 318-510<br />
+
**[[2fxp]] – hscvSpi HR2 motif - NMR<br />
 +
**[[2ghv]] – hscvSpi RBD<br />
 +
**[[5xjk]] – hscvSpi 758-821 - NMR<br />
**[[1wyy]] – hscvSpi 885-1189<br />
**[[1wyy]] – hscvSpi 885-1189<br />
**[[1zv7]], [[1zv8]], [[1zva]], [[1zvb]] – hscvSpi 1150-1193<br />
**[[1zv7]], [[1zv8]], [[1zva]], [[1zvb]] – hscvSpi 1150-1193<br />
**[[6u7h]] – hcv229Spi – human coronavirus 229E – Cryo EM <br />
**[[6u7h]] – hcv229Spi – human coronavirus 229E – Cryo EM <br />
 +
**[[5zuv]], [[5zvm]] – hcv229Spi HR1 motif 785-873 <br />
 +
**[[5yl9]], [[5zhy]] – hcv229Spi HR1+HR2 motifs<br />
**[[5x58]], [[5x5b]] – Spi – human SARS coronavirus BJ01 – Cryo EM <br />
**[[5x58]], [[5x5b]] – Spi – human SARS coronavirus BJ01 – Cryo EM <br />
-
**[[6lxt]] – CV19Spi HR1+HR2 domains 910-988, 1162-1206 – CoVid-19 <br />
 
**[[6vsb]], [[6vxx]], [[6vyb]] – hsc2Spi – human SARS coronavirus 2 – Cryo EM <br />
**[[6vsb]], [[6vxx]], [[6vyb]] – hsc2Spi – human SARS coronavirus 2 – Cryo EM <br />
 +
**[[6lxt]] – hscSpi HR1+HR2 motifs<br />
**[[5szs]] – hcnSpi – human coronavirus NL63 - Cryo EM<br />
**[[5szs]] – hcnSpi – human coronavirus NL63 - Cryo EM<br />
-
**[[2ieq]] – hcnSpi residues 981-1038, 1242-1283 <br />
+
**[[2ieq]] – hcnSpi HR1+HR2 motifs <br />
 +
**[[5gnb]], [[5kwb]] – Spi RBD - human beta coronavirus<br />
**[[6cv0]] – Spi – infectious bronchitis coronavirus – Cryo EM <br />
**[[6cv0]] – Spi – infectious bronchitis coronavirus – Cryo EM <br />
**[[5fyn]] – Spi ectodomain - puumala virus - Cryo EM<br />
**[[5fyn]] – Spi ectodomain - puumala virus - Cryo EM<br />
-
**[[5x59]], [[5x5c]], [[5x5f]] – McvSpi – MERS coronavirus virus – Cryo EM <br />
+
**[[5x59]], [[5x5c]], [[5x5f]], [[6q04]], [[6q05]], [[6q06]], [[6q07]] – McvSpi – MERS coronavirus virus – Cryo EM <br />
**[[5x4r]], [[5x4s]] – McvSpi N-terminal – Cryo EM <br />
**[[5x4r]], [[5x4s]] – McvSpi N-terminal – Cryo EM <br />
 +
**[[5vyh]] – McvSpi N-terminal<br />
**[[4zpw]], [[4kqz]] – McvSpi RBD<br />
**[[4zpw]], [[4kqz]] – McvSpi RBD<br />
 +
**[[4mod]] – McvSpi HR1+HR2 motifs <br />
 +
**[[2lcz]], [[2lcy]] - ZevSpi fusion loop 507-560 - Zaire ebolavirus - NMR<br />
 +
**[[2m5f]], [[2mb1]] - ZevSpi fusion loop (mutant) - NMR<br />
* Human virus spike protein complex
* Human virus spike protein complex
**[[2ajf]] – hscvSpi RBD + ACEH<br />
**[[2ajf]] – hscvSpi RBD + ACEH<br />
 +
**[[6nb6]], [[6nb7]] – hscvSpi + antibody - Cryo EM<br />
**[[2ghw]], [[3bgf]], [[2dd8]] – hscvSpi RBD + antibody<br />
**[[2ghw]], [[3bgf]], [[2dd8]] – hscvSpi RBD + antibody<br />
**[[6lzg]] – hscvSpi RBD + ACE2<br />
**[[6lzg]] – hscvSpi RBD + ACE2<br />
**[[6acg]], [[6acj]], [[6ack]], [[6cs2]] – hscvSpi + ACE2 - Cryo EM<br />
**[[6acg]], [[6acj]], [[6ack]], [[6cs2]] – hscvSpi + ACE2 - Cryo EM<br />
-
**[[6atk]] – hcv229Spi RBD + aminopeptidase <br />
+
**[[6atk]], [[6u7f]], [[6u7g]], [[6u7e]] – hcv229Spi RBD + aminopeptidase <br />
**[[6m0j]], [[3d0g]], [[3d0h]], [[3d0i]], [[3sci]], [[3scj]], [[3sck]], [[3scl]] – hsc2Spi RBD + ACE2<br />
**[[6m0j]], [[3d0g]], [[3d0h]], [[3d0i]], [[3sci]], [[3scj]], [[3sck]], [[3scl]] – hsc2Spi RBD + ACE2<br />
 +
**[[5w41]] – hsc2Spi RBD + antibody<br />
 +
**[[3kbh]] – hcnSpi RBD + ACE2<br />
**[[4kr0]] – McvSpi RBD + CD26<br />
**[[4kr0]] – McvSpi RBD + CD26<br />
-
**[[6pz8]], [[5w9h]], [[5w9i]], [[5w9j]], [[5w9k]] – McvSpi + antibody – Cryo EM <br />
+
**[[6pz8]], [[5w9h]], [[5w9i]], [[5w9j]], [[5w9k]], [[5w9l]], [[5w9m]], [[5w9n]], [[5w9o]], [[5w9p]] – McvSpi + antibody – Cryo EM <br />
**[[6j11]] – McvSpi N-terminal + antibody<br />
**[[6j11]] – McvSpi N-terminal + antibody<br />
-
**[[5yy5]], [[5zxv]] – McvSpi RBD + antibody<br />
+
**[[5yy5]], [[5zxv]], [[4zpt]], [[4zpv]], [[5do2]], [[6c6y]], [[6c6z]], [[4xak]], [[5gmq]] – McvSpi RBD + antibody<br />
 +
**[[4l72]] – McvSpi RBD + DPP4<br />
 +
**[[5zvk]] – McvSpi HR1 motif 984-1062 + peptide inhibitor<br />
 +
**[[6pci]], [[6qd8]] – ZevSpi + antibody – Cryo EM <br />
 +
**[[6uye]] – ZevSpi + SGP – Cryo EM <br />
*Non-human virus spike protein
*Non-human virus spike protein
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**[[4fsc]] – Spi RBD + aminopeptidase – porcine respiratory coronavirus <br />
**[[4fsc]] – Spi RBD + aminopeptidase – porcine respiratory coronavirus <br />
**[[6vsj]] – mcvSpi + MHV-R - Cryo EM<br />
**[[6vsj]] – mcvSpi + MHV-R - Cryo EM<br />
 +
**[[4qzv]] – bcvSpi RBD + DPP4<br />
}}
}}

Revision as of 08:55, 8 April 2020

Human SARS coronavirus trimer (PDB code 5xlr)

Drag the structure with the mouse to rotate

3D Structures of spike protein

Updated on 08-April-2020

References

  1. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Eric Martz, Joel L. Sussman

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