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3iyv

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Revision as of 17:31, 10 April 2020

Clathrin D6 coat as full-length Triskelions

3iyv, resolution 7.90Å

Structural highlights

3iyv is a 18 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1xi4, 1xi5
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CLH1_BOVIN] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. [CLCA_BOVIN] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Clathrin-coated vesicles are important vehicles of membrane traffic in cells. We report the structure of a clathrin lattice at subnanometre resolution, obtained from electron cryomicroscopy of coats assembled in vitro. We trace most of the 1,675-residue clathrin heavy chain by fitting known crystal structures of two segments, and homology models of the rest, into the electron microscopy density map. We also define the position of the central helical segment of the light chain. A helical tripod, the carboxy-terminal parts of three heavy chains, projects inward from the vertex of each three-legged clathrin triskelion, linking that vertex to 'ankles' of triskelions centred two vertices away. Analysis of coats with distinct diameters shows an invariant pattern of contacts in the neighbourhood of each vertex, with more variable interactions along the extended parts of the triskelion 'legs'. These invariant local interactions appear to stabilize the lattice, allowing assembly and uncoating to be controlled by events at a few specific sites.

Molecular model for a complete clathrin lattice from electron cryomicroscopy.,Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T Nature. 2004 Dec 2;432(7017):573-9. Epub 2004 Oct 24. PMID:15502812^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 2;432(7017):573-9. Epub 2004 Oct 24. PMID:15502812 doi:10.1038/nature03079

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3iyv"

@@ Line 3: / Line 3: @@
 <SX load='3iyv' size='340' side='right' viewer='molstar' caption='[[3iyv]], [[Resolution|resolution]] 7.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3iyv]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IYV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3iyv]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IYV FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xi4|1xi4]], [[1xi5|1xi5]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyv OCA], [http://pdbe.org/3iyv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iyv RCSB], [http://www.ebi.ac.uk/pdbsum/3iyv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyv ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3iyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyv OCA], [http://pdbe.org/3iyv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iyv RCSB], [http://www.ebi.ac.uk/pdbsum/3iyv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyv ProSAT]</span></td></tr>
 </table>
 == Function ==

3iyv

From Proteopedia

Revision as of 17:31, 10 April 2020

Clathrin D6 coat as full-length Triskelions

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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