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5x0m
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5x0m is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution== | |
| + | <SX load='5x0m' size='340' side='right' viewer='molstar' caption='[[5x0m]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5x0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_cockroach American cockroach]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X0M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X0M FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x0m OCA], [http://pdbe.org/5x0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x0m RCSB], [http://www.ebi.ac.uk/pdbsum/5x0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x0m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/D0E0C2_PERAM D0E0C2_PERAM]] Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Voltage-gated sodium (Nav) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of channelopathies and are targeted by multiple pharmaceutical drugs and natural toxins. Here, we report the cryogenic electron microscopy structure of a putative Nav channel from American cockroach (designated NavPaS) at 3.8 angstrom resolution. The voltage-sensing domains (VSDs) of the four repeats exhibit distinct conformations. The entrance to the asymmetric selectivity filter vestibule is guarded by heavily glycosylated and disulfide bond-stabilized extracellular loops. On the cytoplasmic side, a conserved amino-terminal domain is placed below VSDI, and a carboxy-terminal domain binds to the III-IV linker. The structure of NavPaS establishes an important foundation for understanding function and disease mechanism of Nav and related voltage-gated calcium channels. | ||
| - | + | Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.,Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N Science. 2017 Mar 3;355(6328). pii: eaal4326. doi: 10.1126/science.aal4326. Epub , 2017 Feb 9. PMID:28183995<ref>PMID:28183995</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5x0m" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: American cockroach]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li, Z]] | ||
| + | [[Category: Pan, X]] | ||
| + | [[Category: Shen, H]] | ||
| + | [[Category: Wu, J]] | ||
| + | [[Category: Yan, N]] | ||
| + | [[Category: Zhou, Q]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
Current revision
Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution
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Categories: American cockroach | Large Structures | Li, Z | Pan, X | Shen, H | Wu, J | Yan, N | Zhou, Q | Ion channel | Membrane protein
