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1b03
From Proteopedia
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[[Image:1b03.gif|left|200px]] | [[Image:1b03.gif|left|200px]] | ||
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'''SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE''' | '''SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1B03 is a [[Single protein]] structure | + | 1B03 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Tugarinov, V.]] | [[Category: Tugarinov, V.]] | ||
[[Category: Zvi, A.]] | [[Category: Zvi, A.]] | ||
| - | [[Category: | + | [[Category: P1053 structure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:54:06 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:54, 2 May 2008
SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE
Overview
The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.
About this Structure
1B03 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide., Tugarinov V, Zvi A, Levy R, Anglister J, Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:10201400 Page seeded by OCA on Fri May 2 10:54:06 2008
