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6ssm

From Proteopedia

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Human endogenous retrovirus (HML2) mature capsid assembly, T=3 icosahedron

6ssm, resolution 4.34Å

Structural highlights

6ssm is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GAK24_HUMAN] The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

Publication Abstract from PubMed

The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and provirus expression together with HML2 particle formation are observed in early stage human embryo development and are associated with pluripotency as well as inflammatory disease, cancers and HIV-1 infection. Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures of four classes of CA Fullerene shell assemblies. These icosahedral and capsular assemblies reveal at high-resolution the molecular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to form the unique polyhedral structures found in retroviral cores.

Structural basis for Fullerene geometry in a human endogenous retrovirus capsid.,Acton O, Grant T, Nicastro G, Ball NJ, Goldstone DC, Robertson LE, Sader K, Nans A, Ramos A, Stoye JP, Taylor IA, Rosenthal PB Nat Commun. 2019 Dec 20;10(1):5822. doi: 10.1038/s41467-019-13786-y. PMID:31862888^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Acton O, Grant T, Nicastro G, Ball NJ, Goldstone DC, Robertson LE, Sader K, Nans A, Ramos A, Stoye JP, Taylor IA, Rosenthal PB. Structural basis for Fullerene geometry in a human endogenous retrovirus capsid. Nat Commun. 2019 Dec 20;10(1):5822. doi: 10.1038/s41467-019-13786-y. PMID:31862888 doi:http://dx.doi.org/10.1038/s41467-019-13786-y

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ssm"

@@ Line 1: / Line 1: @@
 ==Human endogenous retrovirus (HML2) mature capsid assembly, T=3 icosahedron==
-<StructureSection load='6ssm' size='340' side='right'caption='[[6ssm]], [[Resolution|resolution]] 4.34&Aring;' scene=''>
+<SX load='6ssm' size='340' side='right' viewer='molstar' caption='[[6ssm]], [[Resolution|resolution]] 4.34&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6ssm]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SSM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6ssm]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SSM FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ssm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssm OCA], [http://pdbe.org/6ssm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ssm RCSB], [http://www.ebi.ac.uk/pdbsum/6ssm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssm ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ssm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssm OCA], [http://pdbe.org/6ssm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ssm RCSB], [http://www.ebi.ac.uk/pdbsum/6ssm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssm ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 20: / Line 20: @@
 <references/>
 __TOC__
-</StructureSection>
+</SX>
 [[Category: Large Structures]]
 [[Category: Acton, O J.H]]

6ssm

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Current revision

Human endogenous retrovirus (HML2) mature capsid assembly, T=3 icosahedron

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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