User:Fujr Ibrahim/Sandbox 1
From Proteopedia
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | == Introduction to Miraculin == | + | == <h3><span style="color: purple;"> Introduction to Miraculin </span> == |
| + | Miracle? I think you mean Miraculin. | ||
| + | Miraculin is a protein that is best known for its ability to deceive human taste buds into thinking | ||
| + | sour or acidic food is sweet. This homodimeric glycoprotein was first identified in the West | ||
| + | African native fruit, Synsepalum dulcificum (also known as “Miracle Fruit”), and exists in the | ||
| + | pulp of the miracle fruit. | ||
| + | Miraculin’s deceptive properties have been exploited by several companies as sugar substitutes. | ||
| + | However, the American Food and Drug Administration banned the use of miraculin after | ||
| + | labeling it as an additive <ref> https://www.accessdata.fda.gov/cms_ia/importalert_120.html </ref> . This | ||
| + | prevented its commercial use in the food industry. | ||
| - | == What We Know About Miraculin’s Structure == | + | == <h3><span style="color: purple;"> What We Know About Miraculin’s Structure </span> == |
| + | Miraculin is composed of 191 amino acid residues linked primarily by disulfide bonds, | ||
| + | having a molecular weight of about 28 kDa. Sarroch Theerasil et al <ref> | ||
| + | https://www.jbc.org/content/263/23/11536.full.pdf+html </ref> use HPLC profiles and SDS-PAGE | ||
| + | analyses to prove this. | ||
| + | Miraculin is a homodimer made by two chains that have two N-glycosylated Asn residues and | ||
| + | are cross-linked through a disulfide bridge. Miraculin can also exist in a tetramer form. | ||
== Predictivley-modeled structure of miraculin == | == Predictivley-modeled structure of miraculin == | ||
| + | |||
== Miraculin’s interactions with human tongue receptors == | == Miraculin’s interactions with human tongue receptors == | ||
Revision as of 22:08, 12 April 2020
Miraculin, a taste-deceiving protein
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ https://www.accessdata.fda.gov/cms_ia/importalert_120.html
- ↑ https://www.jbc.org/content/263/23/11536.full.pdf+html
