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2jnr

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Revision as of 07:56, 15 April 2020

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

Structural highlights

2jnr is a 2 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[Q72502_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292]

Publication Abstract from PubMed

A variety of molecules in human blood have been implicated in the inhibition of HIV-1. However, it remained elusive which circulating natural compounds are most effective in controlling viral replication in vivo. To identify natural HIV-1 inhibitors we screened a comprehensive peptide library generated from human hemofiltrate. The most potent fraction contained a 20-residue peptide, designated VIRUS-INHIBITORY PEPTIDE (VIRIP), corresponding to the C-proximal region of alpha1-antitrypsin, the most abundant circulating serine protease inhibitor. We found that VIRIP inhibits a wide variety of HIV-1 strains including those resistant to current antiretroviral drugs. Further analysis demonstrated that VIRIP blocks HIV-1 entry by interacting with the gp41 fusion peptide and showed that a few amino acid changes increase its antiretroviral potency by two orders of magnitude. Thus, as a highly specific natural inhibitor of the HIV-1 gp41 fusion peptide, VIRIP may lead to the development of another class of antiretroviral drugs.

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide.,Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F Cell. 2007 Apr 20;129(2):263-75. PMID:17448989^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F. Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell. 2007 Apr 20;129(2):263-75. PMID:17448989 doi:S0092-8674(07)00328-5

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jnr"

@@ Line 1: / Line 1: @@
 ==Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide==
-<StructureSection load='2jnr' size='340' side='right' caption='[[2jnr]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='2jnr' size='340' side='right'caption='[[2jnr]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jnr]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JNR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jnr]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JNR FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnr OCA], [http://pdbe.org/2jnr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jnr RCSB], [http://www.ebi.ac.uk/pdbsum/2jnr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnr ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnr OCA], [http://pdbe.org/2jnr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jnr RCSB], [http://www.ebi.ac.uk/pdbsum/2jnr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnr ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Adermann, K]]
 [[Category: Biet, T]]

2jnr

From Proteopedia

Revision as of 07:56, 15 April 2020

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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