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2jsi

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Revision as of 07:58, 15 April 2020

11-23 obestatin fragment in DPC/SDS micellar solution

Structural highlights

2jsi is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Related:	2jsj, 2jsh
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GHRL_MOUSE] Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).

Publication Abstract from PubMed

Obestatin and its derivative Ob(11-23) are recently discovered peptides produced in the rat stomach. They have proven to be involved in the regulation of energy balance, inhibiting feeding, causing reductions in food intake, body weight and jejunal contraction in rodents. The G-protein coupled receptor, GPR39, was originally proposed as being an obestatin target receptor, but this remains controversial. As such, the molecular mechanism for obestatin's effects in vivo is still uncertain. Here we report the CD and NMR conformational analysis of obestatin and Ob(11-23). Both peptides assume a regular secondary structure in the C-terminal region of the molecule. In this region, structural elements similar to other GPCR binding neuropeptides support the identity of obestatin as a new and functionally autonomous GPCR ligand. Conversely sequence and conformational specificity point to a new farmacoforic structure, on which innovative derivatives with a potential role in the treatment of obesity can be designed and synthetized.

Obestatin conformational features: a strategy to unveil obestatin's biological role?,Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM Biochem Biophys Res Commun. 2007 Nov 23;363(3):500-5. Epub 2007 Sep 19. PMID:17904104^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM. Obestatin conformational features: a strategy to unveil obestatin's biological role? Biochem Biophys Res Commun. 2007 Nov 23;363(3):500-5. Epub 2007 Sep 19. PMID:17904104 doi:http://dx.doi.org/S0006-291X(07)01902-X

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jsi"

@@ Line 1: / Line 1: @@
 ==11-23 obestatin fragment in DPC/SDS micellar solution==
-<StructureSection load='2jsi' size='340' side='right' caption='[[2jsi]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
+<StructureSection load='2jsi' size='340' side='right'caption='[[2jsi]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jsj|2jsj]], [[2jsh|2jsh]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://pdbe.org/2jsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://pdbe.org/2jsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 23: / Line 23: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Campiglia, P]]
 [[Category: Esposito, C]]

2jsi

From Proteopedia

Revision as of 07:58, 15 April 2020

11-23 obestatin fragment in DPC/SDS micellar solution

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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