Huntingtin
From Proteopedia
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==Huntingtin protein== | ==Huntingtin protein== | ||
<StructureSection load='2ld0' size='340' side='right' caption='NMR solution structure of the N-terminal domain of huntingtin (htt17) in 50 % TFE' scene=''> | <StructureSection load='2ld0' size='340' side='right' caption='NMR solution structure of the N-terminal domain of huntingtin (htt17) in 50 % TFE' scene=''> | ||
| - | '''Huntingtin''' (HTT) is a large (350 kDa) protein essential for embryonic development and is involved in a variety of cellular functions, such as vesicular transport, endocytosis, transcription regulation and autophagy. Mutation in the associated gene results in an expansion of the polyQ domain and is the cause of Huntington disease. | + | '''Huntingtin''' (HTT) is a large (350 kDa) protein essential for embryonic development and is involved in a variety of cellular functions, such as vesicular transport, endocytosis, transcription regulation and autophagy. Mutation in the associated gene - IT15 - results in an expansion of the polyQ domain and is the cause of Huntington disease. |
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
Revision as of 11:18, 18 April 2020
Huntingtin protein
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
