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1b7g
From Proteopedia
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[[Image:1b7g.jpg|left|200px]] | [[Image:1b7g.jpg|left|200px]] | ||
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'''GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE''' | '''GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE''' | ||
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==Reference== | ==Reference== | ||
Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus., Isupov MN, Fleming TM, Dalby AR, Crowhurst GS, Bourne PC, Littlechild JA, J Mol Biol. 1999 Aug 20;291(3):651-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10448043 10448043] | Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus., Isupov MN, Fleming TM, Dalby AR, Crowhurst GS, Bourne PC, Littlechild JA, J Mol Biol. 1999 Aug 20;291(3):651-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10448043 10448043] | ||
| - | [[Category: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
[[Category: Isupov, M N.]] | [[Category: Isupov, M N.]] | ||
[[Category: Littlechild, J A.]] | [[Category: Littlechild, J A.]] | ||
| - | [[Category: | + | [[Category: Archaea]] |
| - | [[Category: | + | [[Category: Gapdh]] |
| - | [[Category: | + | [[Category: Hyperthermophile]] |
| - | [[Category: | + | [[Category: Hyperthermophilic dehydrogenase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:10:00 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:10, 2 May 2008
GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE
Overview
The enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the archaea shows low sequence identity (16-20%) with its eubacterial and eukaryotic counterparts. The crystal structure of the apo GAPDH from Sulfolobus solfataricus has been determined by multiple isomorphous replacement at 2.05 A resolution. The enzyme has several differences in secondary structure when compared with eubacterial GAPDHs, with an overall increase in the number of alpha-helices. There is a relocation of the active-site residues within the catalytic domain of the enzyme. The thermostability of the S. solfataricus enzyme can be attributed to a combination of an ion pair cluster and an intrasubunit disulphide bond.
About this Structure
1B7G is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus., Isupov MN, Fleming TM, Dalby AR, Crowhurst GS, Bourne PC, Littlechild JA, J Mol Biol. 1999 Aug 20;291(3):651-60. PMID:10448043 Page seeded by OCA on Fri May 2 11:10:00 2008
