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Synapsin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1px2' size='340' side='right' caption='Rat synapsin 1 complex with ATP anc Ca++ ion (green) (PDB code 1px2)' scene=''> == Function == '''Synapsins''' (SYN) ...) |
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| - | + | <StructureSection load='1px2' size='400' side='right' caption='Rat synapsin 1 complex with ATP and Ca++ ion (green) (PDB code [[1px2]])' scene='84/843883/Cv/1'> | |
| - | <StructureSection load='1px2' size=' | + | |
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== Structural highlights == | == Structural highlights == | ||
| - | The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both hydrogen bonds and Van-der Waals contacts with the protein<ref>PMID:14688264</ref>. | + | The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both <scene name='84/843883/Cv/4'>hydrogen bonds</scene> and <scene name='84/843883/Cv/5'>Van-der Waals contacts</scene> with the protein<ref>PMID:14688264</ref>. Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
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**[[1auv]] - bSYN1A C-terminal 110-421 - bovine<br /> | **[[1auv]] - bSYN1A C-terminal 110-421 - bovine<br /> | ||
**[[1aux]] - bSYN1A C-terminal + ATPgS<br /> | **[[1aux]] - bSYN1A C-terminal + ATPgS<br /> | ||
| - | **[[1pk8]], [[1px2]] - rSYN1 | + | **[[1pk8]], [[1px2]] - rSYN1 + ATP - rat<br /> |
*Synapsin 2 | *Synapsin 2 | ||
Current revision
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3D structures of synapsin
Updated on 30-April-2020
References
- ↑ Cesca F, Baldelli P, Valtorta F, Benfenati F. The synapsins: key actors of synapse function and plasticity. Prog Neurobiol. 2010 Aug;91(4):313-48. doi: 10.1016/j.pneurobio.2010.04.006. Epub, 2010 May 10. PMID:20438797 doi:http://dx.doi.org/10.1016/j.pneurobio.2010.04.006
- ↑ Brautigam CA, Chelliah Y, Deisenhofer J. Tetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin I. J Biol Chem. 2004 Mar 19;279(12):11948-56. Epub 2003 Dec 19. PMID:14688264 doi:10.1074/jbc.M312015200
