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2l5i

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Revision as of 06:59, 6 May 2020

structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)

Structural highlights

2l5i is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2l5j
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RU17_HUMAN] Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.

Publication Abstract from PubMed

The phosphopeptide P140 issued from the spliceosomal U1-70K snRNP protein is recognized by lupus CD4(+) T cells, transiently abolishes T cell reactivity to other spliceosomal peptides in P140-treated MRL/lpr mice, and ameliorates their clinical features. P140 modulates lupus patients' T cell response ex vivo and is currently included in phase IIb clinical trials. Its underlying mechanism of action remains elusive. Here we show that P140 peptide binds a unique cell-surface receptor, the constitutively-expressed chaperone HSC70 protein, known as a presenting-protein. P140 induces apoptosis of activated MRL/lpr CD4(+) T cells. In P140-treated mice, it increases peripheral blood lymphocyte apoptosis and decreases B cell, activated T cell, and CD4(-)CD8(-)B220(+) T cell counts via a specific mechanism strictly depending on gammadelta T cells. Expression of inflammation-linked genes is rapidly regulated in CD4(+) T cells. This work led us to identify a powerful pathway taken by a newly-designed therapeutic peptide to immunomodulate lupus autoimmunity.

The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells.,Page N, Schall N, Strub JM, Quinternet M, Chaloin O, Decossas M, Cung MT, Van Dorsselaer A, Briand JP, Muller S PLoS One. 2009;4(4):e5273. Epub 2009 Apr 23. PMID:19390596^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Page N, Schall N, Strub JM, Quinternet M, Chaloin O, Decossas M, Cung MT, Van Dorsselaer A, Briand JP, Muller S. The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells. PLoS One. 2009;4(4):e5273. Epub 2009 Apr 23. PMID:19390596 doi:10.1371/journal.pone.0005273

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l5i"

@@ Line 1: / Line 1: @@
 ==structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)==
-<StructureSection load='2l5i' size='340' side='right' caption='[[2l5i]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''>
+<StructureSection load='2l5i' size='340' side='right'caption='[[2l5i]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2l5i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L5I FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2l5i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2L5I FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l5j|2l5j]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5i OCA], [http://pdbe.org/2l5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l5i RCSB], [http://www.ebi.ac.uk/pdbsum/2l5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5i ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2l5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5i OCA], [http://pdbe.org/2l5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l5i RCSB], [http://www.ebi.ac.uk/pdbsum/2l5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5i ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 20: / Line 20: @@
 ==See Also==
-*[[Nucleoprotein|Nucleoprotein]]
+*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Briand, J]]
 [[Category: Chaloin, O]]

2l5i

From Proteopedia

Revision as of 06:59, 6 May 2020

structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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