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6s7v
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6s7v is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Lipoteichoic acids flippase LtaA== | |
| + | <StructureSection load='6s7v' size='340' side='right'caption='[[6s7v]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6s7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S7V FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BTN44_07740, FA040_03480, RK64_05390 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7v OCA], [http://pdbe.org/6s7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s7v RCSB], [http://www.ebi.ac.uk/pdbsum/6s7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria, including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell division and antibiotic resistance. Genetic evidence has suggested that LtaA is the flippase that mediates the translocation of the lipid-linked disaccharide that anchors LTA to the cell membrane, a rate-limiting step in S. aureus LTA biogenesis. Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter flippase that contributes to S. aureus survival under physiological acidic conditions. Our results provide foundations for the development of new strategies to counteract S. aureus infections. | ||
| - | + | Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis.,Zhang B, Liu X, Lambert E, Mas G, Hiller S, Veening JW, Perez C Nat Struct Mol Biol. 2020 May 4. pii: 10.1038/s41594-020-0425-5. doi:, 10.1038/s41594-020-0425-5. PMID:32367070<ref>PMID:32367070</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6s7v" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Perez, C]] | ||
| + | [[Category: Zhang, B]] | ||
| + | [[Category: Flippase]] | ||
| + | [[Category: Lipoteichoic acid]] | ||
| + | [[Category: Transport protein]] | ||
Current revision
Lipoteichoic acids flippase LtaA
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