1bd2

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[[Image:1bd2.gif|left|200px]]
[[Image:1bd2.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1bd2", creates the "Structure Box" on the page.
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|GENE= HLA-A 0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 J BETA 2.7 (BV13S1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V ALPHA 17.2, J ALPHA 54 (ADV21S1A1N2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3, J BETA 2.7 (BV13S1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1bd2| PDB=1bd2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bd2 OCA], [http://www.ebi.ac.uk/pdbsum/1bd2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bd2 RCSB]</span>
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'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201'''
'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201'''
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[[Category: Utz, U.]]
[[Category: Utz, U.]]
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
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[[Category: complex (mhc/viral peptide/receptor)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:21:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:58:26 2008''
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Revision as of 08:21, 2 May 2008

Image:1bd2.gif

Template:STRUCTURE 1bd2

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201


Overview

The three-dimensional structure of a human alphabeta T cell receptor (TCR), B7, bound to the HLA-A2 molecule/HTLV-1 Tax peptide complex was determined by x-ray crystallography. Although different from the A6 TCR, previously studied, in 16 of the 17 residues that contact HLA-A2/Tax, the B7 TCR binds in a similar diagonal manner, only slightly tipped and rotated, relative to the A6 TCR. The structure explains data from functional assays on the specificity differences between the B7 and A6 TCRs for agonist, partial agonist, and null peptides. The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on the formation of geometrically defined supramolecular assemblies for initiating signaling.

About this Structure

1BD2 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.

Reference

Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids., Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC, Immunity. 1998 Apr;8(4):403-11. PMID:9586631 Page seeded by OCA on Fri May 2 11:21:30 2008

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