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1bf5

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[[Image:1bf5.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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{{STRUCTURE_1bf5| PDB=1bf5 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bf5 OCA], [http://www.ebi.ac.uk/pdbsum/1bf5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bf5 RCSB]</span>
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'''TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX'''
'''TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX'''
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[[Category: Vinkemeier, U.]]
[[Category: Vinkemeier, U.]]
[[Category: Zhao, Y.]]
[[Category: Zhao, Y.]]
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[[Category: complex (sh2 domain/dna)]]
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[[Category: Sh2 domain]]
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[[Category: sh2 domain]]
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[[Category: Transcription factor]]
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[[Category: transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:59:40 2008''
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Revision as of 08:26, 2 May 2008

Image:1bf5.gif

Template:STRUCTURE 1bf5

TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX


Overview

The crystal structure of the DNA complex of a STAT-1 homodimer has been determined at 2.9 A resolution. STAT-1 utilizes a DNA-binding domain with an immunoglobulin fold, similar to that of NFkappaB and the p53 tumor suppressor protein. The STAT-1 dimer forms a contiguous C-shaped clamp around DNA that is stabilized by reciprocal and highly specific interactions between the SH2 domain of one monomer and the C-terminal segment, phosphorylated on tyrosine, of the other. The phosphotyrosine-binding site of the SH2 domain in each monomer is coupled structurally to the DNA-binding domain, suggesting a potential role for the SH2-phosphotyrosine interaction in the stabilization of DNA interacting elements.

About this Structure

1BF5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA., Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE Jr, Kuriyan J, Cell. 1998 May 29;93(5):827-39. PMID:9630226 Page seeded by OCA on Fri May 2 11:26:06 2008

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