This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6yv4
From Proteopedia
(Difference between revisions)
m (Protected "6yv4" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ==STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT | + | ==STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 686== |
| - | <StructureSection load='6yv4' size='340' side='right'caption='[[6yv4]]' scene=''> | + | <StructureSection load='6yv4' size='340' side='right'caption='[[6yv4]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YV4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6yv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YV4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yv4 OCA], [http://pdbe.org/6yv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/6yv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yv4 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PQK:1-cyclopropyl-2,5-dimethyl-pyrrole-3-carboxylic+acid'>PQK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NOTUM, OK/SW-CL.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Wnt_protein]_O-palmitoleoyl-L-serine_hydrolase [Wnt protein] O-palmitoleoyl-L-serine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.98 3.1.1.98] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yv4 OCA], [http://pdbe.org/6yv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/6yv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yv4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NOTUM_HUMAN NOTUM_HUMAN]] May deacetylate GlcNAc residues on cell surface glycans. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hillier J]] | + | [[Category: Hillier, J]] |
| - | [[Category: Jones | + | [[Category: Jones, E Y]] |
| - | [[Category: Ruza | + | [[Category: Ruza, R R]] |
| + | [[Category: Fragment screen]] | ||
| + | [[Category: Frizzled]] | ||
| + | [[Category: Fzd]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Notum]] | ||
| + | [[Category: Wnt]] | ||
| + | [[Category: Wnt signalling]] | ||
Revision as of 06:43, 3 June 2020
STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 686
| |||||||||||
Categories: Human | Large Structures | Hillier, J | Jones, E Y | Ruza, R R | Fragment screen | Frizzled | Fzd | Hydrolase | Notum | Wnt | Wnt signalling
