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2qil

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Revision as of 07:05, 10 June 2020

TOXIC SHOCK SYNDROME TOXIN-1 AT 2.07 A RESOLUTION

Structural highlights

2qil is a 3 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TSST_STAAU] Responsible for the symptoms of toxic shock syndrome.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus is a causative agent of the toxic shock syndrome disease. It belongs to a family of proteins known as superantigens that cross-link major histocompatibility class II molecules and T-cell receptors leading to the activation of a substantial number of T cells. The crystal structure of this protein has been refined to 2.07 A with an Rcryst value of 20.4% for 51,240 reflections. The final model contains three molecules in the asymmetric unit with good stereochemistry and a root-mean-square deviation of 0.009 A and 1.63 from ideality for bond lengths and bond angles, respectively. The overall fold is considerably similar to that of other known microbial superantigens (staphylococcal enterotoxins). However, a detailed structural analysis shows that toxic shock syndrome toxin-1 lacks several structural features that affect its specificity for V beta elements of the T-cell receptor and also its recognition by major histocompatibility class II molecules.

The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution.,Papageorgiou AC, Brehm RD, Leonidas DD, Tranter HS, Acharya KR J Mol Biol. 1996 Jul 26;260(4):553-69. PMID:8759320^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Papageorgiou AC, Brehm RD, Leonidas DD, Tranter HS, Acharya KR. The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution. J Mol Biol. 1996 Jul 26;260(4):553-69. PMID:8759320

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qil"

@@ Line 1: / Line 1: @@
 ==TOXIC SHOCK SYNDROME TOXIN-1 AT 2.07 A RESOLUTION==
-<StructureSection load='2qil' size='340' side='right' caption='[[2qil]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
+<StructureSection load='2qil' size='340' side='right'caption='[[2qil]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2qil]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2qil]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2QIL FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qil OCA], [http://pdbe.org/2qil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qil RCSB], [http://www.ebi.ac.uk/pdbsum/2qil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qil ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qil OCA], [http://pdbe.org/2qil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qil RCSB], [http://www.ebi.ac.uk/pdbsum/2qil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qil ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 31: / Line 31: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Staphylococcus aureus]]
 [[Category: Acharya, K R]]

2qil

From Proteopedia

Revision as of 07:05, 10 June 2020

TOXIC SHOCK SYNDROME TOXIN-1 AT 2.07 A RESOLUTION

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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