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5iw8

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==Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 4 [5-(3-([1,1'-Biphenyl]-3-yl)ureido)-2-hydroxybenzoic acid]==
==Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 4 [5-(3-([1,1'-Biphenyl]-3-yl)ureido)-2-hydroxybenzoic acid]==
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<StructureSection load='5iw8' size='340' side='right' caption='[[5iw8]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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<StructureSection load='5iw8' size='340' side='right'caption='[[5iw8]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5iw8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IW8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5iw8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IW8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IW8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6EC:5-{[([1,1-BIPHENYL]-3-YL)CARBAMOYL]AMINO}-2-HYDROXYBENZOIC+ACID'>6EC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6EC:5-{[([1,1-BIPHENYL]-3-YL)CARBAMOYL]AMINO}-2-HYDROXYBENZOIC+ACID'>6EC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fgp|3fgp]], [[3dki|3dki]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fgp|3fgp]], [[3dki|3dki]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cysM, Rv1336, MTCY130.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[CysO_sulfur-carrier_protein]-thiocarboxylate-dependent_cysteine_synthase [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.113 2.5.1.113] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[CysO_sulfur-carrier_protein]-thiocarboxylate-dependent_cysteine_synthase [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.113 2.5.1.113] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iw8 OCA], [http://pdbe.org/5iw8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iw8 RCSB], [http://www.ebi.ac.uk/pdbsum/5iw8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iw8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iw8 OCA], [http://pdbe.org/5iw8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iw8 RCSB], [http://www.ebi.ac.uk/pdbsum/5iw8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iw8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
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[[Category: Myctu]]
[[Category: Brunner, K]]
[[Category: Brunner, K]]
[[Category: Schneider, G]]
[[Category: Schneider, G]]

Revision as of 07:19, 10 June 2020

Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 4 [5-(3-([1,1'-Biphenyl]-3-yl)ureido)-2-hydroxybenzoic acid]

PDB ID 5iw8

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