WWP2
From Proteopedia
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| - | This is a default text for your page '''WWP2'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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Revision as of 19:30, 15 June 2020
Contents |
Introduction
WWP2 is a family member of Homologous to the E6-AP Carboxyl Terminus (HECT) E3 Ligases which accept a ubiquitin molecule from an enzyme upstream in the ubiquitination pathway and transfer the ubiquitin to a target signaling molecule or transcription factor. The thioester bond formation between an active site Cystine on HECT E3 Ligases and ubiquitin differentiates this family of enzymes from the more abundant RING family of ubiquitin ligases which do not covalently bond to the ubiquitin ligand. ---
Structure
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Function
Disease
Relevance
Structural highlights
References
Proteopedia Page Contributors and Editors (what is this?)
Tihitina Y Aytenfisu, Hannah Campbell, Sandra B. Gabelli, Michal Harel
