5x8s
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Ursolic acid.== | ==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Ursolic acid.== | ||
| - | <StructureSection load='5x8s' size='340' side='right' caption='[[5x8s]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='5x8s' size='340' side='right'caption='[[5x8s]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5x8s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8S OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[5x8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hylobates_concolor_leucogenys Hylobates concolor leucogenys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X8S FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6Q5:Ursolic+acid'>6Q5</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Q5:Ursolic+acid'>6Q5</scene></td></tr> |
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x8x|5x8x]], [[5x8u|5x8u]], [[5x8w|5x8w]], [[5x8q|5x8q]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x8x|5x8x]], [[5x8u|5x8u]], [[5x8w|5x8w]], [[5x8q|5x8q]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORC, NR1F3, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=61853 Hylobates concolor leucogenys])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8s OCA], [http://pdbe.org/5x8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8s RCSB], [http://www.ebi.ac.uk/pdbsum/5x8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Hylobates concolor leucogenys]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Adachi, T]] | [[Category: Adachi, T]] | ||
[[Category: Doi, S]] | [[Category: Doi, S]] | ||
Revision as of 10:30, 17 June 2020
Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Ursolic acid.
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