1bk6
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1bk6.gif|left|200px]] | [[Image:1bk6.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1bk6", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1bk6| PDB=1bk6 | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS''' | '''KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS''' | ||
| Line 30: | Line 27: | ||
[[Category: Leighton, L.]] | [[Category: Leighton, L.]] | ||
[[Category: Uy, M.]] | [[Category: Uy, M.]] | ||
| - | [[Category: | + | [[Category: Armadillo repeat containing protein]] |
| - | [[Category: | + | [[Category: Nls nuclear import]] |
| - | + | [[Category: Protein transport]] | |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:37:21 2008'' |
| - | + | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:37, 2 May 2008
KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS
Overview
Selective nuclear import is mediated by nuclear localization signals (NLSs) and cognate transport factors known as karyopherins or importins. Karyopherin alpha recognizes "classical" monopartite and bipartite NLSs. We report the crystal structure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha, in the absence and presence of a monopartite NLS peptide at 2.2 A and 2.8 A resolution, respectively. The structure shows a tandem array of ten armadillo repeats, organized in a right-handed superhelix of helices. Binding of the NLS peptide occurs at two sites within a helical surface groove that is lined by conserved residues. The structure reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs.
About this Structure
1BK6 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha., Conti E, Uy M, Leighton L, Blobel G, Kuriyan J, Cell. 1998 Jul 24;94(2):193-204. PMID:9695948 Page seeded by OCA on Fri May 2 11:37:21 2008
