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1bkz
From Proteopedia
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[[Image:1bkz.gif|left|200px]] | [[Image:1bkz.gif|left|200px]] | ||
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'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7''' | '''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7''' | ||
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[[Category: Acharya, K R.]] | [[Category: Acharya, K R.]] | ||
[[Category: Leonidas, D D.]] | [[Category: Leonidas, D D.]] | ||
| - | [[Category: | + | [[Category: Carbohydrate binding]] |
| - | [[Category: | + | [[Category: Galaptin]] |
| - | [[Category: | + | [[Category: Galectin]] |
| - | [[Category: | + | [[Category: Lectin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:39:02 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:39, 2 May 2008
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7
Overview
Knowledge about carbohydrate recognition domains of galectins, formerly known as S-type animal lectins, is important in understanding their role(s) in cell-cell interactions. Here we report the crystal structure of human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This is the first structure of a galectin determined in both free and carbohydrate-bound forms. The structure shows a fold similar to that of the prototype galectins -1 and -2, but has greater similarity to a related galectin molecule, Gal-10. Even though the carbohydrate-binding residues are conserved, there are significant changes in this pocket due to shortening of a loop structure. The monomeric hGal-7 molecule exists as a dimer in the crystals, but adopts a packing arrangement considerably different from that of Gal-1 and Gal-2, which has implications for carbohydrate recognition.
About this Structure
1BKZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:9760227 Page seeded by OCA on Fri May 2 11:39:02 2008
