1bl0

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[[Image:1bl0.gif|left|200px]]
[[Image:1bl0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bl0 |SIZE=350|CAPTION= <scene name='initialview01'>1bl0</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_1bl0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= MARA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1bl0| PDB=1bl0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl0 OCA], [http://www.ebi.ac.uk/pdbsum/1bl0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bl0 RCSB]</span>
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}}
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'''MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX'''
'''MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX'''
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[[Category: Rhee, R G.]]
[[Category: Rhee, R G.]]
[[Category: Rosner, D R.]]
[[Category: Rosner, D R.]]
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[[Category: a bipartite helix-turn-helix protein]]
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[[Category: A bipartite helix-turn-helix protein]]
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[[Category: transcriptional activator]]
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[[Category: Transcriptional activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:39:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:03:12 2008''
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Revision as of 08:39, 2 May 2008

Template:STRUCTURE 1bl0

MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX


Overview

A crystal structure for a member of the AraC prokaryotic transcriptional activator family, MarA, in complex with its cognate DNA-binding site is described. MarA consists of two similar subdomains, each containing a helix-turn-helix DNA-binding motif. The two recognition helices of the motifs are inserted into adjacent major groove segments on the same face of the DNA but are separated by only 27 A thereby bending the DNA by approximately 35 degrees. Extensive interactions between the recognition helices and the DNA major groove provide the sequence specificity.

About this Structure

1BL0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A novel DNA-binding motif in MarA: the first structure for an AraC family transcriptional activator., Rhee S, Martin RG, Rosner JL, Davies DR, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10413-8. PMID:9724717 Page seeded by OCA on Fri May 2 11:39:03 2008

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