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1bm0

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bm0 OCA], [http://www.ebi.ac.uk/pdbsum/1bm0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bm0 RCSB]</span>
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'''CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN'''
'''CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN'''
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[[Category: Noda, M.]]
[[Category: Noda, M.]]
[[Category: Sugio, S.]]
[[Category: Sugio, S.]]
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[[Category: albumin]]
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[[Category: Albumin]]
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[[Category: carrier protein]]
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[[Category: Carrier protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:41:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:03:44 2008''
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Revision as of 08:41, 2 May 2008

Image:1bm0.gif


PDB ID 1bm0

Drag the structure with the mouse to rotate
1bm0, resolution 2.50Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN


Overview

A new triclinic crystal form of human serum albumin (HSA), derived either from pool plasma (pHSA) or from a Pichia pastoris expression system (rHSA), was obtained from polyethylene glycol 4000 solution. Three-dimensional structures of pHSA and rHSA were determined at 2.5 A resolution from the new triclinic crystal form by molecular replacement, using atomic coordinates derived from a multiple isomorphous replacement work with a known tetragonal crystal form. The structures of pHSA and rHSA are virtually identical, with an r.m. s. deviation of 0.24 A for all Calpha atoms. The two HSA molecules involved in the asymmetric unit are related by a strict local twofold symmetry such that the Calpha atoms of the two molecules can be superimposed with an r.m.s. deviation of 0.28 A in pHSA. Cys34 is the only cysteine with a free sulfhydryl group which does not participate in a disulfide linkage with any external ligand. Domains II and III both have a pocket formed mostly of hydrophobic and positively charged residues and in which a very wide range of compounds may be accommodated. Three tentative binding sites for long-chain fatty acids, each with different surroundings, are located at the surface of each domain.

About this Structure

1BM0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human serum albumin at 2.5 A resolution., Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K, Protein Eng. 1999 Jun;12(6):439-46. PMID:10388840 Page seeded by OCA on Fri May 2 11:41:00 2008

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