1boy

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[[Image:1boy.gif|left|200px]]
[[Image:1boy.gif|left|200px]]
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{{Structure
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|PDB= 1boy |SIZE=350|CAPTION= <scene name='initialview01'>1boy</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1boy", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=7A1:Core+Binding+Site+For+Factor+Viia+Forming+Concavity+Betw+...'>7A1</scene>, <scene name='pdbsite=7A2:Distal+Part+Of+Binding+Site+For+Factor+Viia+On+Convex+Su+...'>7A2</scene> and <scene name='pdbsite=XA1:Site+Of+Interaction+w.+Macromolecular+Substrate+Xa+Which+...'>XA1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= HUMAN TISSUE FACTOR CDNA CODON ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1boy| PDB=1boy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1boy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1boy OCA], [http://www.ebi.ac.uk/pdbsum/1boy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1boy RCSB]</span>
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'''EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR'''
'''EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR'''
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[[Category: Harlos, K.]]
[[Category: Harlos, K.]]
[[Category: Tuddenham, E G.D.]]
[[Category: Tuddenham, E G.D.]]
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[[Category: blood coagulation]]
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[[Category: Blood coagulation]]
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[[Category: class 2 cytokine receptor]]
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[[Category: Class 2 cytokine receptor]]
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[[Category: cofactor for factor viia]]
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[[Category: Cofactor for factor viia]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: initiator of blood coagulation in vertebrate]]
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[[Category: Initiator of blood coagulation in vertebrate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:47:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:05:21 2008''
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Revision as of 08:47, 2 May 2008

Image:1boy.gif

Template:STRUCTURE 1boy

EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR


Overview

Tissue factor is a cell-surface glycoprotein receptor which initiates the blood coagulation cascade after vessel injury by interacting with blood clotting factor VII/VIIa and which is implicated in various pathological processes. When bound to tissue factor, factor VII is readily converted to the active protease factor VIIa by trace amounts of factors Xa, IXa or VIIa. Human tissue factor consists of 263 residues, the first 219 of which comprise the extracellular region. We have determined the crystal structure of the extracellular region at a resolution of 2.2 A. Tissue factor consists of two immunoglobulin-like domains associated through an extensive, novel, interdomain interface region. The binding site for factor VII lies at the interface region and involves residues from domain 1 and an extended loop (binding 'finger') of domain 2. This is the first reported structure of a representative of the class 2 cytokine receptor family, which also includes interferon-alpha, interferon-gamma (refs 2, 3) and interleukin-10 (ref. 4) receptors.

About this Structure

1BOY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular region of human tissue factor., Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW, Nature. 1994 Aug 25;370(6491):662-6. PMID:8065454 Page seeded by OCA on Fri May 2 11:47:03 2008

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