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1okc

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Revision as of 07:33, 25 June 2020

structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

Structural highlights

1okc is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ADT1_BOVIN] Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by a single protein, the ADP/ATP carrier. Here we have solved the bovine carrier structure at a resolution of 2.2 A by X-ray crystallography in complex with an inhibitor, carboxyatractyloside. Six alpha-helices form a compact transmembrane domain, which, at the surface towards the space between inner and outer mitochondrial membranes, reveals a deep depression. At its bottom, a hexapeptide carrying the signature of nucleotide carriers (RRRMMM) is located. Our structure, together with earlier biochemical results, suggests that transport substrates bind to the bottom of the cavity and that translocation results from a transient transition from a 'pit' to a 'channel' conformation.

Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside.,Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G Nature. 2003 Nov 6;426(6962):39-44. PMID:14603310^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature. 2003 Nov 6;426(6962):39-44. PMID:14603310 doi:http://dx.doi.org/10.1038/nature02056

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1okc"

@@ Line 1: / Line 1: @@
 ==structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside==
-<StructureSection load='1okc' size='340' side='right' caption='[[1okc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='1okc' size='340' side='right'caption='[[1okc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1okc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OKC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1okc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1OKC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CXT:CARBOXYATRACTYLOSIDE'>CXT</scene>, <scene name='pdbligand=LDM:3-LAURYLAMIDO-N,N-DIMETHYLPROPYLAMINOXYDE'>LDM</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CXT:CARBOXYATRACTYLOSIDE'>CXT</scene>, <scene name='pdbligand=LDM:3-LAURYLAMIDO-N,N-DIMETHYLPROPYLAMINOXYDE'>LDM</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1okc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1okc OCA], [http://pdbe.org/1okc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1okc RCSB], [http://www.ebi.ac.uk/pdbsum/1okc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1okc ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1okc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1okc OCA], [http://pdbe.org/1okc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1okc RCSB], [http://www.ebi.ac.uk/pdbsum/1okc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1okc ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Bos taurus]]
+[[Category: Large Structures]]
 [[Category: Brandolin, G]]
 [[Category: Dahout-Gonzalez, C]]

1okc

From Proteopedia

Revision as of 07:33, 25 June 2020

structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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