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2w1b

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Revision as of 08:46, 25 June 2020

The structure of the efflux pump AcrB in complex with bile acid

Structural highlights

2w1b is a 1 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	1oy8, 1t9u, 1iwg, 1t9t, 1t9y, 1t9w, 2j8s, 1oy6, 1t9x, 2gif, 2hrt, 1oye, 1oyd, 1oy9, 1t9v
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.^[1] ^[2] ^[3]

Publication Abstract from PubMed

Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.

The structure of the efflux pump AcrB in complex with bile acid.,Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K Mol Membr Biol. 2008 Dec;25(8):677-82. PMID:19023693^[4]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007
↑ Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K. The structure of the efflux pump AcrB in complex with bile acid. Mol Membr Biol. 2008 Dec;25(8):677-82. PMID:19023693 doi:905752382

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w1b"

@@ Line 1: / Line 1: @@
 ==The structure of the efflux pump AcrB in complex with bile acid==
-<StructureSection load='2w1b' size='340' side='right' caption='[[2w1b]], [[Resolution|resolution]] 3.85&Aring;' scene=''>
+<StructureSection load='2w1b' size='340' side='right'caption='[[2w1b]], [[Resolution|resolution]] 3.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W1B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1B OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W1B FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1oy8|1oy8]], [[1t9u|1t9u]], [[1iwg|1iwg]], [[1t9t|1t9t]], [[1t9y|1t9y]], [[1t9w|1t9w]], [[2j8s|2j8s]], [[1oy6|1oy6]], [[1t9x|1t9x]], [[2gif|2gif]], [[2hrt|2hrt]], [[1oye|1oye]], [[1oyd|1oyd]], [[1oy9|1oy9]], [[1t9v|1t9v]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1b OCA], [http://pdbe.org/2w1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w1b RCSB], [http://www.ebi.ac.uk/pdbsum/2w1b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1b ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1b OCA], [http://pdbe.org/2w1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w1b RCSB], [http://www.ebi.ac.uk/pdbsum/2w1b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1b ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 24: / Line 24: @@
 </StructureSection>
 [[Category: Ecoli]]
+[[Category: Large Structures]]
 [[Category: Beis, K]]
 [[Category: Drew, D]]

2w1b

From Proteopedia

Revision as of 08:46, 25 June 2020

The structure of the efflux pump AcrB in complex with bile acid

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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