CAMP-dependent protein kinase 3D structures

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*'''PKA catalytic subunit'''
*'''PKA catalytic subunit'''
 +
**[[4ae6]], [[4ae9]] – hPKA 2 – human<br />
**[[1j3h]] – mPKA – mouse
**[[1j3h]] – mPKA – mouse
**[[1syk]], [[4dfy]], [[4nts]] - mPKA (mutant)
**[[1syk]], [[4dfy]], [[4nts]] - mPKA (mutant)
 +
**[[6eh0]] – haPKA – hamster<br />
**[[1fot]] - yPKA – yeast<br />
**[[1fot]] - yPKA – yeast<br />
-
**[[4ae6]], [[4ae9]] – hPKA 2 – human<br />
 
-
**[[6eh0]] – haPKA – hamster<br />
 
*PKA catalytic subunit binary complex
*PKA catalytic subunit binary complex
-
**[[4ntt]] – mPKA (mutant) + ADP<br />
 
-
**[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br />
 
-
**[[6em2]] - haPKA + fasudil<br />
 
**[[6c0u]] - hPKA + inhibitor<br />
**[[6c0u]] - hPKA + inhibitor<br />
-
**[[3bwj]] - bPKA + bisubstrate inhibitor<br />
 
**[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br />
**[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br />
 +
**[[3bwj]] - bPKA + bisubstrate inhibitor<br />
 +
**[[1szm]] - bPKA + bisindolymaleimide<br />
 +
**[[3ag9]] - bPKA + inhibitor<br />
 +
**[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br />
 +
**[[6em2]] - haPKA + fasudil<br />
 +
**[[4ntt]] – mPKA (mutant) + ADP<br />
**[[1bkx]] – mPKA + adenosine<br />
**[[1bkx]] – mPKA + adenosine<br />
**[[3o7l]] – mPKA + phospholamban<br />
**[[3o7l]] – mPKA + phospholamban<br />
**[[1bx6]], [[1re8]], [[1rej]], [[1rek]] - mPKA + balanol analog<br />
**[[1bx6]], [[1re8]], [[1rej]], [[1rek]] - mPKA + balanol analog<br />
-
**[[1szm]] - bPKA + bisindolymaleimide<br />
 
-
**[[3ag9]] - bPKA + inhibitor<br />
 
*PKA catalytic subunit binary complex with peptide inhibitor
*PKA catalytic subunit binary complex with peptide inhibitor
-
**[[2cpk]], [[1ctp]], [[1fmo]], [[1l3r]], [[1xh4]], [[1xh5]], [[1xh6]], [[1xh7]], [[1xh8]], [[1xh9]], [[1xha]], [[3fjq]], [[4dg0]], [[4dg2]], [[4dh1]], [[4dh3]], [[4dh5]], [[4dh7]], [[4dh8]], [[4hpt]], [[4hpu]], [[4xw6]], [[4xw5]], [[4xw4]], [[3x2w]], [[3x2v]], [[3x2u]] – mPKA + peptide inhibitor<br />
 
-
**[[1q61]], [[1q62]], [[1smh]], [[2qur]], [[3qal]], [[3qam]], [[4dfx]], [[4dfz]], [[4dg3]] - mPKA (mutant) + peptide inhibitor<br />
 
-
**[[4iac]], [[4iad]], [[4iaf]], [[4iai]], [[4iak]], [[4iay]], [[4iaz]], [[4ib0]], **[[4ib1]], [[4ib3]], [[4o22]] – mPKA + SP20 peptide<br />
 
-
**[[2gfc]], [[3dnd]], [[3dne]], [[3kkv]], [[3zo1]], [[3zo2]], [[3zo3]], [[3zo4]], [[4ie9]], [[4ij9]], [[4yxs]], [[4yxr]] - bPKA + peptide inhibitor<br />
 
-
**[[4wih]], [[5lcp]], [[5lcq]], [[5lcr]], [[5lct]], [[5lcu]], [[5m0u]] - haPKA + peptide inhibitor <br />
 
-
**[[2gng]], [[4axa]], [[4c33]], [[4c34]], [[4c35]], [[4c36]], [[4c37]], [[4c38]] - bPKA (mutant) + peptide inhibitor<br />
 
**[[3mvj]], [[3oog]], [[3poo]], [[3vqh]], [[5j5x]], [[5izj]], [[5izf]], [[5bx7]], [[5bx6]], [[4ujb]], [[4uja]], [[4uj9]], [[4uj2]], [[4uj1]] - hPKA + peptide inhibitor<br />
**[[3mvj]], [[3oog]], [[3poo]], [[3vqh]], [[5j5x]], [[5izj]], [[5izf]], [[5bx7]], [[5bx6]], [[4ujb]], [[4uja]], [[4uj9]], [[4uj2]], [[4uj1]] - hPKA + peptide inhibitor<br />
**[[4z84]], [[4z83]] - hPKA (mutant) + peptide inhibitor<br />
**[[4z84]], [[4z83]] - hPKA (mutant) + peptide inhibitor<br />
-
**[[4wb5]], [[4wb6]], [[4wb8]] – mPKA (mutant) + PKI peptide<br />
+
**[[2gfc]], [[3dnd]], [[3dne]], [[3kkv]], [[3zo1]], [[3zo2]], [[3zo3]], [[3zo4]], [[4ie9]], [[4ij9]], [[4yxs]], [[4yxr]] - bPKA + peptide inhibitor<br />
 +
**[[2gng]], [[4axa]], [[4c33]], [[4c34]], [[4c35]], [[4c36]], [[4c37]], [[4c38]] - bPKA (mutant) + peptide inhibitor<br />
**[[1cdk]] - pPKA + peptide inhibitor – pig<br />
**[[1cdk]] - pPKA + peptide inhibitor – pig<br />
 +
**[[2cpk]], [[1ctp]], [[1fmo]], [[1l3r]], [[1xh4]], [[1xh5]], [[1xh6]], [[1xh7]], [[1xh8]], [[1xh9]], [[1xha]], [[3fjq]], [[4dg0]], [[4dg2]], [[4dh1]], [[4dh3]], [[4dh5]], [[4dh7]], [[4dh8]], [[4hpt]], [[4hpu]], [[4xw6]], [[4xw5]], [[4xw4]], [[3x2w]], [[3x2v]], [[3x2u]] – mPKA + peptide inhibitor<br />
 +
**[[1q61]], [[1q62]], [[1smh]], [[2qur]], [[3qal]], [[3qam]], [[4dfx]], [[4dfz]], [[4dg3]] - mPKA (mutant) + peptide inhibitor<br />
 +
**[[4iac]], [[4iad]], [[4iaf]], [[4iai]], [[4iak]], [[4iay]], [[4iaz]], [[4ib0]] - mPKA + PSP20 peptide<br />
 +
**[[4ib1]], [[4ib3]], [[4o22]] – mPKA + SP20 peptide<br />
 +
**[[6mm5]] – mPKA + RYR2 peptide<br />
 +
**[[6mm6]], [[6mm7]], [[6mm8]] – mPKA + RYR2 phosphorylation domain<br />
 +
**[[4wb5]], [[4wb6]], [[4wb8]] – mPKA (mutant) + PKI peptide<br />
 +
**[[4wih]], [[5lcp]], [[5lcq]], [[5lcr]], [[5lct]], [[5lcu]], [[5m0u]] - haPKA + peptide inhibitor <br />
*PKA catalytic subunit ternary complex
*PKA catalytic subunit ternary complex
-
**[[1apm]], [[1jlu]] - mPKA + detergent + peptide inhibitor<br />
+
**[[2gu8]], [[3l9l]], [[3ovv]], [[3owp]], [[3oxt]], [[3p0m]], [[5uzk]] - hPKA catalytic subunit + peptide inhibitor + inhibitor<br />
-
**[[2erz]] - mPKA + peptide inhibitor + hydroxyfasudil<br />
+
**[[3nx8]] - hPKA catalytic subunit + peptide inhibitor + phenol<br />
-
**[[1cmk]] - pPKA + peptide inhibitor + myristic acid<br />
+
**[[3l9m]], [[3l9n]], [[3ama]], [[3amb]] - hPKA (mutant) + peptide inhibitor + inhibitor<br />
 +
**[[3wyg]] – hPKA + GSP1P + exportin<br />
 +
**[[6qj7]] – hPKA + PKI + inhibitor<br />
**[[1stc]] - bPKA + peptide inhibitor + saturosporine<br />
**[[1stc]] - bPKA + peptide inhibitor + saturosporine<br />
**[[2gnh]], [[2gni]], [[2gnj]], [[2gnl]], [[2jdv]], [[2uvx]], [[2uvy]], [[2uvz]], [[2uw0]], [[2uw3]], [[2uw4]], [[2uw5]], [[2uw6]], [[2uw7]], [[2uw8]], [[2vnw]], [[2vny]], [[2vo0]], [[2vo3]], [[2vo6]], [[2vo7]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
**[[2gnh]], [[2gni]], [[2gnj]], [[2gnl]], [[2jdv]], [[2uvx]], [[2uvy]], [[2uvz]], [[2uw0]], [[2uw3]], [[2uw4]], [[2uw5]], [[2uw6]], [[2uw7]], [[2uw8]], [[2vnw]], [[2vny]], [[2vo0]], [[2vo3]], [[2vo6]], [[2vo7]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
-
**[[1ydr]], [[1yds]], [[1ydt]], [[2c1a]], [[2c1b]], [[2oh0]], [[2ojf]], [[2uzt]], [[2uzu]], [[2uzv]], [[2uzw]], [[2f7e]], [[2f7x]], [[2f7z]], [[2jds]], [[5vib]] - bPKA + peptide inhibitor + inhibitor<br />
+
**[[1ydr]], [[1yds]], [[1ydt]], [[2c1a]], [[2c1b]], [[2oh0]], [[2ojf]], [[2uzt]], [[2uzu]], [[2uzv]], [[2uzw]], [[2f7e]], [[2f7x]], [[2f7z]], [[2jds]], [[5vib]], [[6e99]], [[6e9l]], [[5vhb]] - bPKA + peptide inhibitor + inhibitor<br />
**[[2jdt]], [[5vi9]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
**[[2jdt]], [[5vi9]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
**[[3e8c]], [[3e8e]] - bPKA catalytic subunit + peptide inhibitor + ATP-competitive inhibitor<br />
**[[3e8c]], [[3e8e]] - bPKA catalytic subunit + peptide inhibitor + ATP-competitive inhibitor<br />
Line 54: Line 59:
**[[2gnf]] - bPKA (mutant) + peptide inhibitor + rho-kinase inhibitor<br />
**[[2gnf]] - bPKA (mutant) + peptide inhibitor + rho-kinase inhibitor<br />
**[[1sve]], [[1svg]], [[1svh]], [[1veb]] - bPKA + detergent + peptide inhibitor + azepane derivative<br />
**[[1sve]], [[1svg]], [[1svh]], [[1veb]] - bPKA + detergent + peptide inhibitor + azepane derivative<br />
-
**[[2gu8]], [[3l9l]], [[3ovv]], [[3owp]], [[3oxt]], [[3p0m]], [[5uzk]] - hPKA catalytic subunit + peptide inhibitor + inhibitor<br />
+
**[[1cmk]] - pPKA + peptide inhibitor + myristic acid<br />
-
**[[3nx8]] - hPKA catalytic subunit + peptide inhibitor + phenol<br />
+
-
**[[3l9m]], [[3l9n]], [[3ama]], [[3amb]] - hPKA (mutant) + peptide inhibitor + inhibitor<br />
+
-
**[[3wyg]] – hPKA + GSP1P + exportin<br />
+
**[[3ow3]] - mPKA catalytic subunit + peptide inhibitor + inhibitor<br />
**[[3ow3]] - mPKA catalytic subunit + peptide inhibitor + inhibitor<br />
 +
**[[1apm]], [[1jlu]] - mPKA + detergent + peptide inhibitor<br />
 +
**[[2erz]] - mPKA + peptide inhibitor + hydroxyfasudil<br />
**[[5mhi]], [[5n1d]], [[5n1e]], [[5n1k]], [[5n1l]], [[5n1m]], [[5n1n]], [[5n1o]], [[5n32]], [[5n33]], [[5n36]], [[5n37]], [[5n39]], [[5n3a]], [[5n3b]], [[5n3c]], [[5n3d]], [[5n3e]], [[5n3f]], [[5n7p]], [[5n7u]] - haPKA + peptide inhibitor + fragment molecule<br />
**[[5mhi]], [[5n1d]], [[5n1e]], [[5n1k]], [[5n1l]], [[5n1m]], [[5n1n]], [[5n1o]], [[5n32]], [[5n33]], [[5n36]], [[5n37]], [[5n39]], [[5n3a]], [[5n3b]], [[5n3c]], [[5n3d]], [[5n3e]], [[5n3f]], [[5n7p]], [[5n7u]] - haPKA + peptide inhibitor + fragment molecule<br />
**[[6f14]], [[6frx]], [[6erv]], [[6eru]], [[6ert]], [[6i2h]], [[6emd]], [[6i2b]], [[6eh3]], [[6egw]], [[5ous]], [[5ouc]], [[5oua]], [[5otg]], [[5ot3]], [[5ol3]], [[5ok3]], [[5o5m]], [[5o0e]], [[5nw8]], [[5ntj]] - haPKA + peptide inhibitor + inhibitor<br />
**[[6f14]], [[6frx]], [[6erv]], [[6eru]], [[6ert]], [[6i2h]], [[6emd]], [[6i2b]], [[6eh3]], [[6egw]], [[5ous]], [[5ouc]], [[5oua]], [[5otg]], [[5ot3]], [[5ol3]], [[5ok3]], [[5o5m]], [[5o0e]], [[5nw8]], [[5ntj]] - haPKA + peptide inhibitor + inhibitor<br />
**[[6erw]], [[6ers]], [[6emb]], [[5m75]], [[5m71]], [[5m6y]], [[5m6v]], [[5m0l]], [[5m0c]], [[5m0b]] - haPKA + peptide inhibitor + fasudil derivative<br />
**[[6erw]], [[6ers]], [[6emb]], [[5m75]], [[5m71]], [[5m6y]], [[5m6v]], [[5m0l]], [[5m0c]], [[5m0b]] - haPKA + peptide inhibitor + fasudil derivative<br />
 +
**[[6i2a]] - haPKA + RPK153 + fasudil <br />
 +
**[[6i2c]], [[6i2d]] - haPKA + RPK182 + fasudil <br />
*PKA catalytic subunit ternary complex with nucleotide
*PKA catalytic subunit ternary complex with nucleotide
 +
**[[1q24]] - bPKA + peptide inhibitor + Mg-ATP<br />
**[[1jbp]] - mPKA + detergent + peptide inhibitor + ADP<br />
**[[1jbp]] - mPKA + detergent + peptide inhibitor + ADP<br />
**[[1rdq]] - mPKA + peptide inhibitor + ADP + ATP<br />
**[[1rdq]] - mPKA + peptide inhibitor + ADP + ATP<br />
**[[4o21]] - mPKA + peptide inhibitor + ATP-G-S<br />
**[[4o21]] - mPKA + peptide inhibitor + ATP-G-S<br />
**[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br />
**[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br />
-
**[[1q24]] - bPKA + peptide inhibitor + Mg-ATP<br />
 
-
**[[6ema]] - haPKA + peptide inhibitor + inhibitor + ATP<br />
 
**[[6e21]] - mPKA + peptide inhibitor + ADP<br />
**[[6e21]] - mPKA + peptide inhibitor + ADP<br />
**[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br />
**[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br />
**[[6eh2]] - haPKA + peptide inhibitor + inhibitor + AMP<br />
**[[6eh2]] - haPKA + peptide inhibitor + inhibitor + AMP<br />
**[[6esa]] - haPKA + peptide inhibitor + ribose + AMP<br />
**[[6esa]] - haPKA + peptide inhibitor + ribose + AMP<br />
 +
**[[6ema]] - haPKA + peptide inhibitor + inhibitor + ATP<br />
*PKA regulatory subunit
*PKA regulatory subunit
-
**[[1cx4]] - rPKA II-β cAMP-binding domain – rat<br />
+
**[[4f9k]] – hPKA I-β<br />
-
**[[1r2a]] - mPKA II dimerization-anchoring domain – NMR<br />
+
-
**[[1l6e]] - mPKA II-α dimerization-anchoring domain – NMR<br />
+
-
**[[2ezw]] - bPKA I-α dimerization-anchoring domain – bovine - NMR<br />
+
**[[1ne4]], [[1ne6]], [[1rl3]], [[3iia]], [[1rgs]], [[4mx3]] - bPKA <br />
**[[1ne4]], [[1ne6]], [[1rl3]], [[3iia]], [[1rgs]], [[4mx3]] - bPKA <br />
 +
**[[2ezw]] - bPKA I-α dimerization-anchoring domain - NMR<br />
**[[3im3]] - bPKA I-α dimerization-anchoring domain<br />
**[[3im3]] - bPKA I-α dimerization-anchoring domain<br />
**[[3pna]] - bPKA I-α cAMP-binding domain<br />
**[[3pna]] - bPKA I-α cAMP-binding domain<br />
 +
**[[1cx4]] - rPKA II-β cAMP-binding domain – rat<br />
 +
**[[1r2a]] - mPKA II dimerization-anchoring domain – NMR<br />
 +
**[[1l6e]] - mPKA II-α dimerization-anchoring domain – NMR<br />
**[[3of1]] - yPKA <br />
**[[3of1]] - yPKA <br />
-
**[[4f9k]] – hPKA I-β<br />
 
*PKA regulatory subunit binary complex
*PKA regulatory subunit binary complex
-
**[[2drn]], [[2h9r]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide – NMR<br />
 
**[[2izx]], [[2izy]], [[4zp3]] - hPKA II-α + A-kinase anchoring protein peptide<br />
**[[2izx]], [[2izy]], [[4zp3]] - hPKA II-α + A-kinase anchoring protein peptide<br />
-
**[[3im4]], [[5hvz]] - bPKA I-α + A-kinase anchoring protein peptide<br />
 
-
**[[2hwn]] - rPKA II-α + A-kinase binding peptide<br />
 
-
**[[4jva]] – rPKA II-β + cAMP analog<br />
 
-
**[[4jv4]] – bPKA I-α + cAMP analog<br />
 
**[[2kyg]] - hPKA II-α + CBFA2T1<br />
**[[2kyg]] - hPKA II-α + CBFA2T1<br />
**[[5kjx]] - hPKA I-α + cAMP<br />
**[[5kjx]] - hPKA I-α + cAMP<br />
**[[5kjy]], [[5kjz]] - hPKA I-α (mutant) + cAMP<br />
**[[5kjy]], [[5kjz]] - hPKA I-α (mutant) + cAMP<br />
 +
**[[3im4]], [[5hvz]] - bPKA I-α + A-kinase anchoring protein peptide<br />
 +
**[[4jv4]] – bPKA I-α + cAMP analog<br />
**[[3plq]] - bPKA I-α + cAMP derivative<br />
**[[3plq]] - bPKA I-α + cAMP derivative<br />
 +
**[[2hwn]] - rPKA II-α + A-kinase binding peptide<br />
 +
**[[4jva]] – rPKA II-β + cAMP analog<br />
 +
**[[2drn]], [[2h9r]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide – NMR<br />
**[[5t3n]] - PfPKA + cAMP derivative – ''Plasmodium falciparum''<br />
**[[5t3n]] - PfPKA + cAMP derivative – ''Plasmodium falciparum''<br />
**[[5kbf]], [[5k8s]] - PfPKA + cAMP <br />
**[[5kbf]], [[5k8s]] - PfPKA + cAMP <br />
Line 109: Line 115:
*PKA catalytic and regulatory subunits
*PKA catalytic and regulatory subunits
-
**[[6bys]] – hPKA<br />
+
**[[6bys]], [[6no7]] – hPKA<br />
**[[2qvs]], [[3idb]], [[3idc]], [[3pvb]], [[4din]], [[4x6q]], [[4wbb]] - mPKA <br />
**[[2qvs]], [[3idb]], [[3idc]], [[3pvb]], [[4din]], [[4x6q]], [[4wbb]] - mPKA <br />
**[[3fhi]], [[2qcs]], [[3tnp]], [[3tnq]], [[4x6r]] - mPKA (mutant) <br />
**[[3fhi]], [[2qcs]], [[3tnp]], [[3tnq]], [[4x6r]] - mPKA (mutant) <br />

Revision as of 09:21, 29 June 2020

3D structures of cAMP-dependent protein kinase

Updated on 29-June-2020

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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