1c0c

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[[Image:1c0c.gif|left|200px]]
[[Image:1c0c.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1c0c |SIZE=350|CAPTION= <scene name='initialview01'>1c0c</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1c0c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1c0c| PDB=1c0c | SCENE= }}
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|RELATEDENTRY=[[1bel|1BEL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c0c OCA], [http://www.ebi.ac.uk/pdbsum/1c0c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c0c RCSB]</span>
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}}
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'''BOVINE PANCREATIC RIBONUCLEASE A DESICCATED FOR 4.0 DAYS'''
'''BOVINE PANCREATIC RIBONUCLEASE A DESICCATED FOR 4.0 DAYS'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Bell, J A.]]
[[Category: Bell, J A.]]
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[[Category: dehydrated]]
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[[Category: Dehydrated]]
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[[Category: desiccated]]
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[[Category: Desiccated]]
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[[Category: dry]]
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[[Category: Dry]]
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[[Category: hydrolase (phosphoric diester]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:11:01 2008''
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[[Category: rna)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:12:02 2008''
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Revision as of 09:11, 2 May 2008

Image:1c0c.gif

Template:STRUCTURE 1c0c

BOVINE PANCREATIC RIBONUCLEASE A DESICCATED FOR 4.0 DAYS


Overview

Unlike most protein crystals, form IX of bovine pancreatic ribonuclease A diffracts well when severely dehydrated. Crystal structures have been solved after 2.5 and 4 days of desiccation with CaSO4, at 1.9 and 2.0 A resolution, respectively. The two desiccated structures are very similar. An RMS displacement of 1.6 A is observed for main-chain atoms in each structure when compared to the hydrated crystal structure with some large rearrangements observed in loop regions. The structural changes are the result of intermolecular contacts formed by strong electrostatic interactions in the absence of a high dielectric medium. The electron density is very diffuse for some surface loops, consistent with a very disordered structure. This disorder is related to the conformational changes. These results help explain conformational changes during the lyophilization of protein and the associated phenomena of denaturation and molecular memory.

About this Structure

1C0C is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

X-ray crystal structures of a severely desiccated protein., Bell JA, Protein Sci. 1999 Oct;8(10):2033-40. PMID:10548049 Page seeded by OCA on Fri May 2 12:11:01 2008

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