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Elongation factor 3D structures

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(New page: ==3D structures of elongation factor== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *EF-Tu **1efm, 1efc...)
Line 6: Line 6:
*EF-Tu
*EF-Tu
 +
**[[1ls2]] – yEF + Phe-tRNA – yeast – Cryo EM<BR />
**[[1efm]], [[1efc]], [[1dg1]], [[2fx3]], [[1etu]], [[5mi3]] – EcEF – ''Escherichia coli''<BR />
**[[1efm]], [[1efc]], [[1dg1]], [[2fx3]], [[1etu]], [[5mi3]] – EcEF – ''Escherichia coli''<BR />
**[[5mi8]], [[5mi9]] – EcEF (mutant) <br />
**[[5mi8]], [[5mi9]] – EcEF (mutant) <br />
Line 14: Line 15:
**[[1ttt]], [[1ob5]] – TaEF + Phe-tRNA + GDPNP - ''Thermus aquaticus''<BR />
**[[1ttt]], [[1ob5]] – TaEF + Phe-tRNA + GDPNP - ''Thermus aquaticus''<BR />
**[[1b23]] - TaEF + Cys-tRNA<BR />
**[[1b23]] - TaEF + Cys-tRNA<BR />
-
**[[1ls2]] – yEF + Phe-tRNA – yeast – Cryo EM<BR />
 
**[[3wxm]] – ApEF + plethora protein – ''Aeropyrum pernix''<br />
**[[3wxm]] – ApEF + plethora protein – ''Aeropyrum pernix''<br />
**[[4h9g]], [[4lbv]], [[4lbw]], [[4lby]], [[4lbz]], [[4lc0]] – TtEF – ''Thermus thermophilus''<br />
**[[4h9g]], [[4lbv]], [[4lbw]], [[4lby]], [[4lbz]], [[4lc0]] – TtEF – ''Thermus thermophilus''<br />
Line 33: Line 33:
*''EF-Tu complex with nucleotide''
*''EF-Tu complex with nucleotide''
 +
**[[1d2e]] – bEF + GDP – bovine<BR />
**[[6eze]] – EcEF + GDP derivative<BR />
**[[6eze]] – EcEF + GDP derivative<BR />
**[[5opd]] – EcEF + GTP <BR />
**[[5opd]] – EcEF + GTP <BR />
Line 38: Line 39:
**[[1eft]] – TaEF + GNP – ''Thermus aquaticus''<BR />
**[[1eft]] – TaEF + GNP – ''Thermus aquaticus''<BR />
**[[1tui]] – TaEF + GDP<BR />
**[[1tui]] – TaEF + GDP<BR />
-
**[[1d2e]] – bEF + GDP – bovine<BR />
 
**[[1jny]], [[1skq]] – SsEF + GDP – ''Sulfolobus solfataricus''<br />
**[[1jny]], [[1skq]] – SsEF + GDP – ''Sulfolobus solfataricus''<br />
**[[3wya]] – PhEF + GDP - ''Pyrococcus horikoshii''<br />
**[[3wya]] – PhEF + GDP - ''Pyrococcus horikoshii''<br />
Line 54: Line 54:
*''EF-Tu with EF-Ts''
*''EF-Tu with EF-Ts''
 +
**[[1xb2]] – bEF + EF-Ts - bovine<BR />
 +
**[[1f60]] – yEF + EF-Ts C terminal<BR />
 +
**[[1g7c]] - yEF + EF-Ts C terminal + GDPNP<BR />
 +
**[[1ije]], [[1ijf]] - yEF + EF-Ts C terminal + GDP<BR />
 +
**[[2b7b]] - yEF + EF-Ts C terminal (mutant) + GDP<BR />
 +
**[[2b7c]] - yEF + EF-Ts C terminal (mutant)<br />
**[[1efu]], [[3agp]], [[3agq]], [[4pc1]] – EcEF + EcEF-Ts<BR />
**[[1efu]], [[3agp]], [[3agq]], [[4pc1]] – EcEF + EcEF-Ts<BR />
**[[3avt]], [[3avu]] , [[3avv]], [[3avw]], [[3avx]], [[3avy]], [[3vnu]] , [[3vnv]], [[4fwt]] – EcEF + EcEF-Ts + RNA<br />
**[[3avt]], [[3avu]] , [[3avv]], [[3avw]], [[3avx]], [[3avy]], [[3vnu]] , [[3vnv]], [[4fwt]] – EcEF + EcEF-Ts + RNA<br />
Line 62: Line 68:
**[[4pc2]], [[4pc3]], [[4pc6]] – EcEF + EcEF-Ts + GDP derivative<br />
**[[4pc2]], [[4pc3]], [[4pc6]] – EcEF + EcEF-Ts + GDP derivative<br />
**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
-
**[[1xb2]] – bEF + EF-Ts - bovine<BR />
 
-
**[[1f60]] – yEF + EF-Ts C terminal<BR />
 
-
**[[1g7c]] - yEF + EF-Ts C terminal + GDPNP<BR />
 
-
**[[1ije]], [[1ijf]] - yEF + EF-Ts C terminal + GDP<BR />
 
-
**[[2b7b]] - yEF + EF-Ts C terminal (mutant) + GDP<BR />
 
-
**[[2b7c]] - yEF + EF-Ts C terminal (mutant)
 
*''EF-Tu in the ribosome''
*''EF-Tu in the ribosome''
Line 80: Line 80:
**[[1tfi]] – hEF – human – NMR<BR />
**[[1tfi]] – hEF – human – NMR<BR />
**[[3ndq]] - hEF domain II<BR />
**[[3ndq]] - hEF domain II<BR />
 +
**[[1wjt]] – mEF N terminal – mouse – NMR<BR />
**[[1enw]] – yEF domain II – NMR<BR />
**[[1enw]] – yEF domain II – NMR<BR />
**[[1eo0]] - yEF domain I – NMR<BR />
**[[1eo0]] - yEF domain I – NMR<BR />
-
**[[2xex]] – SaEF – ''Staphylococcus aureus''<BR />
 
**[[1pqv]], [[1y1v]] – yEF + RNA polymerase II<BR />
**[[1pqv]], [[1y1v]] – yEF + RNA polymerase II<BR />
**[[1y1y]], [[3gtm]] – yEF + RNA polymerase II + RNA<BR />
**[[1y1y]], [[3gtm]] – yEF + RNA polymerase II + RNA<BR />
-
**[[1wjt]] – mEF N terminal – mouse – NMR<BR />
+
**[[2xex]] – SaEF – ''Staphylococcus aureus''<BR />
**[[2m1h]] – EF PWWP domain – ''Trypanosoma brucei'' – NMR<br />
**[[2m1h]] – EF PWWP domain – ''Trypanosoma brucei'' – NMR<br />
Line 100: Line 100:
**[[1fnm]], [[2bm0]], [[2bm1]] – TtEF (mutant) <BR />
**[[1fnm]], [[2bm0]], [[2bm1]] – TtEF (mutant) <BR />
**[[2bcw]] – TtEF + L11 + L7/L12 <br />
**[[2bcw]] – TtEF + L11 + L7/L12 <br />
-
**[[2xex]] – SaEF<BR />
 
-
**[[3zz0]], [[3zzt]], [[3zzu]] – SaEF (mutant) <BR />
 
**[[2bv3]] - TtEF (mutant) + GTP analog<br />
**[[2bv3]] - TtEF (mutant) + GTP analog<br />
**[[2j7k]] - TtEF (mutant) + GDP analog<br />
**[[2j7k]] - TtEF (mutant) + GDP analog<br />
Line 114: Line 112:
**[[6bk7]] – EF N terminal – ''Enterococcus faecalis''<br />
**[[6bk7]] – EF N terminal – ''Enterococcus faecalis''<br />
**[[6n0i]] – PpEF 2<br />
**[[6n0i]] – PpEF 2<br />
 +
**[[2xex]] – SaEF<BR />
 +
**[[3zz0]], [[3zzt]], [[3zzu]] – SaEF (mutant) <BR />
*''EF-G in the ribosome''
*''EF-G in the ribosome''
**[[4v8u]], [[4v5m]], [[4v5n]] – TtEF in 70S ribosome <BR />
**[[4v8u]], [[4v5m]], [[4v5n]] – TtEF in 70S ribosome <BR />
 +
**[[2om7]], [[4v5f]] – TtEF in 70S ribosome – Cryo EM<BR />
**[[4v9h]], [[4v9j]], [[4v9k]], [[4v9l]], [[4v9m]], [[4v90]] – TtEF in 30S ribosome <BR />
**[[4v9h]], [[4v9j]], [[4v9k]], [[4v9l]], [[4v9m]], [[4v90]] – TtEF in 30S ribosome <BR />
**[[4v9o]], [[4v9p]] – EcEF in 30S ribosome <BR />
**[[4v9o]], [[4v9p]] – EcEF in 30S ribosome <BR />
**[[4v9d]] – EcEF in 30S ribosome + antibiotics – Cryo-EM<BR />
**[[4v9d]] – EcEF in 30S ribosome + antibiotics – Cryo-EM<BR />
-
**[[2om7]], [[4v5f]] – TtEF in 70S ribosome – Cryo EM<BR />
 
**[[1zn0]], [[2rdo]], [[3j0e]], [[4v6t]], [[4v9b]] – EcEF in 30S ribosome – Cryo-EM<BR />
**[[1zn0]], [[2rdo]], [[3j0e]], [[4v6t]], [[4v9b]] – EcEF in 30S ribosome – Cryo-EM<BR />
Line 151: Line 151:
*EF-Ts
*EF-Ts
-
**[[1tfe]] – TtEF<BR />
+
**[[2uz8]] – hEF (mutant)<br />
**[[1b64]] – hEF guanine exchange factor domain – NMR<BR />
**[[1b64]] – hEF guanine exchange factor domain – NMR<BR />
-
**[[2cp9]] – UBA domain – NMR<BR />
+
**[[2cp9]] – hEF UBA domain – NMR<BR />
**[[1gh8]] – EF – ''Methanobacterium thermoautotrophicum'' – NMR<BR />
**[[1gh8]] – EF – ''Methanobacterium thermoautotrophicum'' – NMR<BR />
**[[2yy3]] – PhEF <BR />
**[[2yy3]] – PhEF <BR />
-
**[[2uz8]] – hEF (mutant)
+
**[[1tfe]] – TtEF<BR />
*EF-1
*EF-1
Line 172: Line 172:
*EF-2
*EF-2
 +
**[[4v4b]] - hEF in 40S ribosome – Cryo EM<BR />
 +
**[[4cxg]], [[4cxh]] - rEF in 40S ribosome – Cryo EM<BR />
**[[1n0v]] – yEF<BR />
**[[1n0v]] – yEF<BR />
**[[1u2r]] – yEF + GDP<BR />
**[[1u2r]] – yEF + GDP<BR />
**[[1n0u]], [[2e1r]], [[2npf]] – yEF + antifungal drug<BR />
**[[1n0u]], [[2e1r]], [[2npf]] – yEF + antifungal drug<BR />
**[[1zm2]], [[1zm3]], [[1zm4]], [[1zm9]], [[3b78]], [[3b82]], [[3b8h]], [[2zit]] – yEF + exotoxin<BR />
**[[1zm2]], [[1zm3]], [[1zm4]], [[1zm9]], [[3b78]], [[3b82]], [[3b8h]], [[2zit]] – yEF + exotoxin<BR />
-
**[[4v4b]] - hEF in 40S ribosome – Cryo EM<BR />
 
-
**[[4cxg]], [[4cxh]] - rEF in 40S ribosome – Cryo EM<BR />
 
**[[2p8w]], [[2p8x]], [[3dny]] - yEF in 80S ribosome – Cryo EM<BR />
**[[2p8w]], [[2p8x]], [[3dny]] - yEF in 80S ribosome – Cryo EM<BR />
**[[2p8y]], [[2p8z]] - yEF+ antifungal drug in 80S ribosome – Cryo EM<BR />
**[[2p8y]], [[2p8z]] - yEF+ antifungal drug in 80S ribosome – Cryo EM<BR />
Line 199: Line 199:
*EF-SelB
*EF-SelB
 +
**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />
**[[1lva]] – MtEF C terminal – ''Moorella thermoacetica''<BR />
**[[1lva]] – MtEF C terminal – ''Moorella thermoacetica''<BR />
**[[2v9v]] – MtEF winged helix domain<BR />
**[[2v9v]] – MtEF winged helix domain<BR />
Line 208: Line 209:
**[[4ac9]] – MmEF + GDP<BR />
**[[4ac9]] – MmEF + GDP<BR />
**[[2pjp]] – EcEF + RNA<br />
**[[2pjp]] – EcEF + RNA<br />
-
**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />
 
*EF-Spt4 + EF-Spt5
*EF-Spt4 + EF-Spt5
-
**[[5xon]], [[5xog]] – EF-Spt4 + EF-Spt5 + EF-Tfiis + RNA polymerase II - ''Komagataella phaffii'' - Cryo EM<br />
+
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
-
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
 
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
 +
**[[5xon]], [[5xog]] – EF-Spt4 + EF-Spt5 + EF-Tfiis + RNA polymerase II - ''Komagataella phaffii'' - Cryo EM<br />
*EF-Spt5
*EF-Spt5
Line 234: Line 234:
*EF-Spt6
*EF-Spt6
-
**[[3gxw]], [[3gxx]], [[3pjp]] – EF SH2 domain – ''Candida glabrata''<BR />
+
**[[4z2n]] – hEF middle domain residues 644-930<br />
 +
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
**[[3psj]], [[3psk]] – yEF SH2 domain residues 1247-1451<BR />
**[[3psj]], [[3psk]] – yEF SH2 domain residues 1247-1451<BR />
Line 240: Line 241:
**[[2l3t]] - yEF SH2 domain - NMR<BR />
**[[2l3t]] - yEF SH2 domain - NMR<BR />
**[[3oak]] – yEF + transcription factor IWS1<br />
**[[3oak]] – yEF + transcription factor IWS1<br />
-
**[[4z2n]] – hEF middle domain residues 644-930<br />
+
**[[3gxw]], [[3gxx]], [[3pjp]] – EF SH2 domain – ''Candida glabrata''<BR />
-
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
+
*EF-Spt16
*EF-Spt16

Revision as of 09:27, 20 July 2020

3D structures of elongation factor

Updated on 20-July-2020


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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