This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2y6c
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger== | ==The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger== | ||
| - | <StructureSection load='2y6c' size='340' side='right' caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6C OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y6C FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mmp|1mmp]], [[1mmr|1mmr]], [[1mmq|1mmq]], [[2y6d|2y6d]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mmp|1mmp]], [[1mmr|1mmr]], [[1mmq|1mmq]], [[2y6d|2y6d]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Matrilysin Matrilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.23 3.4.24.23] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Matrilysin Matrilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.23 3.4.24.23] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [http://pdbe.org/2y6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [http://www.ebi.ac.uk/pdbsum/2y6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6c ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 13: | Line 13: | ||
==See Also== | ==See Also== | ||
| - | *[[Matrix metalloproteinase|Matrix metalloproteinase]] | + | *[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 19: | Line 19: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Matrilysin]] | [[Category: Matrilysin]] | ||
[[Category: Edman, K]] | [[Category: Edman, K]] | ||
Revision as of 12:36, 22 July 2020
The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger
| |||||||||||
Categories: Human | Large Structures | Matrilysin | Edman, K | Furber, M | Hemsley, P | Johansson, C | Pairaudeau, G | Petersen, J | Stocks, M | Tervo, A | Ward, A | Wells, E | Wissler, L | Hydrolase
