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2y8p

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Revision as of 12:39, 22 July 2020

Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli

Structural highlights

2y8p is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[EMTA_ECOLI] Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. Prefers cross-linked murein in vivo.

Publication Abstract from PubMed

The crystal structure of the first endolytic peptidoglycan lytic transglycosylase MltE from Escherichia coli is reported here. The degradative activity of this enzyme initiates the process of cell wall recycling, which is an integral event in the existence of bacteria. The structure sheds light on how MltE recognizes its substrate, the cell wall peptidoglycan. It also explains the ability of this endolytic enzyme to cleave in the middle of the peptidoglycan chains. Furthermore, the structure reveals how the enzyme is sequestered on the inner leaflet of the outer membrane.

High-Resolution Crystal Structure of MltE, an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase from Escherichia coli.,Artola-Recolons C, Carrasco-Lopez C, Llarrull LI, Kumarasiri M, Lastochkin E, Martinez de Ilarduya I, Meindl K, Uson I, Mobashery S, Hermoso JA Biochemistry. 2011 Apr 5;50(13):2384-2386. Epub 2011 Mar 8. PMID:21341761^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Artola-Recolons C, Carrasco-Lopez C, Llarrull LI, Kumarasiri M, Lastochkin E, Martinez de Ilarduya I, Meindl K, Uson I, Mobashery S, Hermoso JA. High-Resolution Crystal Structure of MltE, an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase from Escherichia coli. Biochemistry. 2011 Apr 5;50(13):2384-2386. Epub 2011 Mar 8. PMID:21341761 doi:10.1021/bi200085y

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2y8p"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli==
-<StructureSection load='2y8p' size='340' side='right' caption='[[2y8p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='2y8p' size='340' side='right'caption='[[2y8p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2y8p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8P FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2y8p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y8P FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8p OCA], [http://pdbe.org/2y8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8p RCSB], [http://www.ebi.ac.uk/pdbsum/2y8p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8p ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8p OCA], [http://pdbe.org/2y8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8p RCSB], [http://www.ebi.ac.uk/pdbsum/2y8p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8p ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 22: @@
 </StructureSection>
 [[Category: Ecoli]]
+[[Category: Large Structures]]
 [[Category: Artola-Recolons, C]]
 [[Category: Carrasco-Lopez, C]]

2y8p

From Proteopedia

Revision as of 12:39, 22 July 2020

Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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