1c8c

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[[Image:1c8c.gif|left|200px]]
[[Image:1c8c.gif|left|200px]]
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{{Structure
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|PDB= 1c8c |SIZE=350|CAPTION= <scene name='initialview01'>1c8c</scene>, resolution 1.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1c8c", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1c8c| PDB=1c8c | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8c OCA], [http://www.ebi.ac.uk/pdbsum/1c8c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c8c RCSB]</span>
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'''CRYSTAL STRUCTURES OF THE CHROMOSOMAL PROTEINS SSO7D/SAC7D BOUND TO DNA CONTAINING T-G MISMATCHED BASE PAIRS'''
'''CRYSTAL STRUCTURES OF THE CHROMOSOMAL PROTEINS SSO7D/SAC7D BOUND TO DNA CONTAINING T-G MISMATCHED BASE PAIRS'''
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[[Category: Su, S.]]
[[Category: Su, S.]]
[[Category: Wang, A H.J.]]
[[Category: Wang, A H.J.]]
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[[Category: achaeabacteria]]
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[[Category: Achaeabacteria]]
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[[Category: dna binding protein]]
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[[Category: Dna binding protein]]
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[[Category: electrostatic]]
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[[Category: Electrostatic]]
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[[Category: hyperthermophile]]
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[[Category: Hyperthermophile]]
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[[Category: molecular modeling]]
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[[Category: Molecular modeling]]
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[[Category: protein stability]]
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[[Category: Protein stability]]
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[[Category: protein-dna interaction]]
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[[Category: Protein-dna interaction]]
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[[Category: t-g mismatch]]
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[[Category: T-g mismatch]]
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[[Category: x-ray crystallography]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:27:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:16:37 2008''
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Revision as of 09:27, 2 May 2008

Image:1c8c.gif

Template:STRUCTURE 1c8c

CRYSTAL STRUCTURES OF THE CHROMOSOMAL PROTEINS SSO7D/SAC7D BOUND TO DNA CONTAINING T-G MISMATCHED BASE PAIRS


Overview

Sso7d and Sac7d are two small chromatin proteins from the hyperthermophilic archaeabacterium Sulfolobus solfataricus and Sulfolobus acidocaldarius, respectively. The crystal structures of Sso7d-GTGATCGC, Sac7d-GTGATCGC and Sac7d-GTGATCAC have been determined and refined at 1.45 A, 2.2 A and 2.2 A, respectively, to investigate the DNA binding property of Sso7d/Sac7d in the presence of a T-G mismatch base-pair. Detailed structural analysis revealed that the intercalation site includes the T-G mismatch base-pair and Sso7d/Sac7d bind to that mismatch base-pair in a manner similar to regular DNA. In the Sso7d-GTGATCGC complex, a new inter-strand hydrogen bond between T2O4 and C14N4 is formed and well-order bridging water molecules are found. The results suggest that the less stable DNA stacking site involving a T-G mismatch may be a preferred site for protein side-chain intercalation.

About this Structure

1C8C is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs., Su S, Gao YG, Robinson H, Liaw YC, Edmondson SP, Shriver JW, Wang AH, J Mol Biol. 2000 Oct 27;303(3):395-403. PMID:11031116 Page seeded by OCA on Fri May 2 12:27:09 2008

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