Factor inhibiting HIF
From Proteopedia
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| - | For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>. | + | For details on '''Factor inhibiting HIF''' or '''Hypoxia-inducible factor 1-alpha inhibitor''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen<ref>PMID:23606740</ref>. <scene name='48/480806/Cv/5'>Dimeric factor inhibiting HIF with oxogluterate derivative</scene>. |
<scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref> | <scene name='48/480806/Cv/6'>Fe/2-oxogluterate binding site</scene> (PDB code [[1mzf]]).<ref>PMID:12432100</ref> | ||
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**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br /> | **[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br /> | ||
**[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]] - hFIH1α + consensus ankyrin repeat peptide<br /> | **[[4b7e]], [[4b7k]], [[4jaa]], [[4nr1]] - hFIH1α + consensus ankyrin repeat peptide<br /> | ||
| + | **[[6h9j]], [[6ha6]] - hFIH1α + TRPV3 peptide + oxalylglycine<br /> | ||
| + | **[[6hc8]] - hFIH1α + TRPA1 peptide + oxalylglycine<br /> | ||
| + | **[[6hl6]] - hFIH1α + ASPP peptide + oxalylglycine<br /> | ||
| + | **[[6hl5]] - hFIH1α + ASPP1 peptide + oxalylglycine<br /> | ||
| + | **[[6hkp]] - hFIH1α + ASPP2 peptide + oxalylglycine<br /> | ||
| + | **[[6ruj]] - hFIH1α + ankyrin repeat + oxalylglycine<br /> | ||
*FIH2α | *FIH2α | ||
Revision as of 08:56, 26 July 2020
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3D Structures of factor inhibiting HIF
Updated on 26-July-2020
References
- ↑ Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013, Apr 19. PMID:23606740 doi:http://dx.doi.org/10.1242/jcs.117564
- ↑ Dann CE 3rd, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15351-6. Epub 2002 Nov 13. PMID:12432100 doi:http://dx.doi.org/10.1073/pnas.202614999
