1c8z
From Proteopedia
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'''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN''' | '''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN''' | ||
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[[Category: Shapiro, L.]] | [[Category: Shapiro, L.]] | ||
[[Category: 12-stranded-beta-barrel]] | [[Category: 12-stranded-beta-barrel]] | ||
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| - | [[Category: | + | [[Category: Deafness]] |
| - | [[Category: | + | [[Category: Filled-beta-roll]] |
| - | [[Category: | + | [[Category: Helix-filled-barrel]] |
| - | [[Category: | + | [[Category: Obesity blindness]] |
| - | [[Category: | + | [[Category: Tubby filled-barrel]] |
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Revision as of 09:28, 2 May 2008
C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN
Overview
Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
About this Structure
1C8Z is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637 Page seeded by OCA on Fri May 2 12:28:38 2008
