1c9c

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[[Image:1c9c.jpg|left|200px]]
[[Image:1c9c.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1c9c |SIZE=350|CAPTION= <scene name='initialview01'>1c9c</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1c9c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PP3:ALANYL-PYRIDOXAL-5&#39;-PHOSPHATE'>PP3</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1c9c| PDB=1c9c | SCENE= }}
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|RELATEDENTRY=[[1cq6|1CQ6]], [[1cq7|1CQ7]], [[1cq8|1CQ8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9c OCA], [http://www.ebi.ac.uk/pdbsum/1c9c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c9c RCSB]</span>
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}}
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'''ASPARTATE AMINOTRANSFERASE COMPLEXED WITH C3-PYRIDOXAL-5'-PHOSPHATE'''
'''ASPARTATE AMINOTRANSFERASE COMPLEXED WITH C3-PYRIDOXAL-5'-PHOSPHATE'''
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[[Category: Kuramitsu, S.]]
[[Category: Kuramitsu, S.]]
[[Category: Nakai, T.]]
[[Category: Nakai, T.]]
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[[Category: enzyme-substrate complex]]
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[[Category: Enzyme-substrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:29:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:17:15 2008''
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Revision as of 09:29, 2 May 2008

Image:1c9c.jpg

Template:STRUCTURE 1c9c

ASPARTATE AMINOTRANSFERASE COMPLEXED WITH C3-PYRIDOXAL-5'-PHOSPHATE


Overview

Domain movement is sometimes essential for substrate recognition by an enzyme. X-ray crystallography of aminotransferase with a series of aliphatic substrates showed that the domain movement of aspartate aminotransferase was changed dramatically from an open to a closed form by the addition of only one CH(2) to the side chain of the C4 substrate CH(3)(CH(2))C((alpha))H(NH(3)(+))COO(-). These crystallographic results and reaction kinetics (Kawaguchi, S., Nobe, Y., Yasuoka, J., Wakamiya, T., Kusumoto, S., and Kuramitsu, S. (1997) J. Biochem. (Tokyo) 122, 55-63; Kawaguchi, S. and Kuramitsu, S. (1998) J. Biol. Chem. 273, 18353-18364) enabled us to estimate the free energy required for the domain movement.

About this Structure

1C9C is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Free energy requirement for domain movement of an enzyme., Ishijima J, Nakai T, Kawaguchi S, Hirotsu K, Kuramitsu S, J Biol Chem. 2000 Jun 23;275(25):18939-45. PMID:10858450 Page seeded by OCA on Fri May 2 12:29:24 2008

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