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2v31
From Proteopedia
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| - | {{STRUCTURE_2v31| PDB=2v31 | SCENE= }} | ||
| - | ===Structure of First Catalytic Cysteine Half-domain of mouse ubiquitin- activating enzyme=== | ||
| - | ==Function== | + | ==Structure of First Catalytic Cysteine Half-domain of mouse ubiquitin- activating enzyme== |
| + | <StructureSection load='2v31' size='340' side='right'caption='[[2v31]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2v31]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V31 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V31 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z7l|1z7l]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v31 OCA], [http://pdbe.org/2v31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v31 RCSB], [http://www.ebi.ac.uk/pdbsum/2v31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v31 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/UBA1_MOUSE UBA1_MOUSE]] Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. | [[http://www.uniprot.org/uniprot/UBA1_MOUSE UBA1_MOUSE]] Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. | ||
| - | + | == Evolutionary Conservation == | |
| - | == | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v3/2v31_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v31 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Ubiquitin activating enzyme|Ubiquitin activating enzyme]] | *[[Ubiquitin activating enzyme|Ubiquitin activating enzyme]] | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Bochtler, M | + | [[Category: Bochtler, M]] |
| - | [[Category: Filipek, R | + | [[Category: Filipek, R]] |
| - | [[Category: Jaremko, L | + | [[Category: Jaremko, L]] |
| - | [[Category: Jaremko, M | + | [[Category: Jaremko, M]] |
| - | [[Category: Szczepanowski, R H | + | [[Category: Szczepanowski, R H]] |
| - | [[Category: Wojciechowski, W | + | [[Category: Wojciechowski, W]] |
| - | [[Category: Zhukov, I | + | [[Category: Zhukov, I]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
Current revision
Structure of First Catalytic Cysteine Half-domain of mouse ubiquitin- activating enzyme
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Categories: Large Structures | Mus musculus | Bochtler, M | Filipek, R | Jaremko, L | Jaremko, M | Szczepanowski, R H | Wojciechowski, W | Zhukov, I | Atp-binding | Catalytic domain | E1 protein | First catalytic cysteine half-domain | Heteronuclear nmr | Ligase | Nucleotide-binding | Phosphorylation | Ubiquitination | Ubl conjugation pathway
