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2z0u

From Proteopedia

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{{Seed}}
 
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[[Image:2z0u.png|left|200px]]
 
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==Crystal structure of C2 domain of KIBRA protein==
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The line below this paragraph, containing "STRUCTURE_2z0u", creates the "Structure Box" on the page.
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<StructureSection load='2z0u' size='340' side='right'caption='[[2z0u]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z0u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z0U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0u OCA], [http://pdbe.org/2z0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z0u RCSB], [http://www.ebi.ac.uk/pdbsum/2z0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0u ProSAT], [http://www.topsan.org/Proteins/RSGI/2z0u TOPSAN]</span></td></tr>
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{{STRUCTURE_2z0u| PDB=2z0u | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of C2 domain of KIBRA protein===
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[[http://www.uniprot.org/uniprot/KIBRA_HUMAN KIBRA_HUMAN]] Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.<ref>PMID:15081397</ref> <ref>PMID:16684779</ref> <ref>PMID:18190796</ref> <ref>PMID:18596123</ref> <ref>PMID:18672031</ref> <ref>PMID:20159598</ref> <ref>PMID:23778582</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2Z0U is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0U OCA].
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<jmolCheckbox>
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[[Category: Homo sapiens]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z0u_consurf.spt"</scriptWhenChecked>
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[[Category: Kato-Murayama, M.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Murayama, K.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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</jmolCheckbox>
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[[Category: Shirouzu, M.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z0u ConSurf].
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[[Category: Terada, T.]]
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<div style="clear:both"></div>
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[[Category: Yokoyama, S.]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Kato-Murayama, M]]
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[[Category: Murayama, K]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu, M]]
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[[Category: Terada, T]]
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[[Category: Yokoyama, S]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: C2 domain]]
[[Category: C2 domain]]
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Polymorphism]]
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[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rsgi]]
[[Category: Rsgi]]
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[[Category: Structural genomic]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 09:45:54 2008''
 

Current revision

Crystal structure of C2 domain of KIBRA protein

PDB ID 2z0u

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