Glutaminyl cyclase
From Proteopedia
(Difference between revisions)
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**[[2afm]], [[2afo]] – hQC – human <br /> | **[[2afm]], [[2afo]] – hQC – human <br /> | ||
**[[2afs]], [[2zed]], [[2zee]], [[2zef]], [[2zeg]], [[2zeh]], [[2zel]], [[2zem]], [[2zen]], [[2zeo]], [[2zep]], [[3pbe]], [[4yu9]] – hQC (mutant) <br /> | **[[2afs]], [[2zed]], [[2zee]], [[2zef]], [[2zeg]], [[2zeh]], [[2zel]], [[2zem]], [[2zen]], [[2zeo]], [[2zep]], [[3pbe]], [[4yu9]] – hQC (mutant) <br /> | ||
| - | **[[3si1]] | + | **[[3si1]] – mQC – mouse <br /> |
| + | **[[4fwu]], [[4f9u]] – DmQC – ''Drosophila melanogaster'' <br /> | ||
| + | **[[4f9v]] – DmQC (mutant) <br /> | ||
**[[3mbr]] – QC – ''Xanthomonas campestris'' <br /> | **[[3mbr]] – QC – ''Xanthomonas campestris'' <br /> | ||
**[[3nol]] – QC – ''Zymomonas mobilis'' <br /> | **[[3nol]] – QC – ''Zymomonas mobilis'' <br /> | ||
**[[3nok]] – QC – ''Myxococcus xanthus''<br /> | **[[3nok]] – QC – ''Myxococcus xanthus''<br /> | ||
| - | **[[4fwu]], [[4f9u]] – DmQC – ''Drosophila melanogaster'' <br /> | ||
| - | **[[4f9v]] – DmQC (mutant) <br /> | ||
*Glutaminyl cyclase complex | *Glutaminyl cyclase complex | ||
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**[[3pbb]] – hQC + inhibitor <br /> | **[[3pbb]] – hQC + inhibitor <br /> | ||
**[[4ywy]], [[6gbx]] – hQC (mutant) + inhibitor <br /> | **[[4ywy]], [[6gbx]] – hQC (mutant) + inhibitor <br /> | ||
| + | **[[6yi1]] – hQC + Glu-(γ-hydrazide)-Phe -Ala<br /> | ||
| + | **[[6yjy]] – hQC + neurotensin<br /> | ||
**[[3si2]] – mQC + inhibitor <br /> | **[[3si2]] – mQC + inhibitor <br /> | ||
}} | }} | ||
Revision as of 07:51, 4 August 2020
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3D Structures of glutaminyl cyclase
Updated on 04-August-2020
References
- ↑ Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS. An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes. J Biol Chem. 1987 Jun 25;262(18):8532-6. PMID:3597387
- ↑ Valenti MT, Bolognin S, Zanatta C, Donatelli L, Innamorati G, Pampanin M, Zanusso G, Zatta P, Dalle Carbonare L. Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. J Alzheimers Dis. 2013;34(1):263-71. doi: 10.3233/JAD-120517. PMID:23207485 doi:http://dx.doi.org/10.3233/JAD-120517
- ↑ Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13117-22. Epub 2005 Aug 31. PMID:16135565
