1ce4
From Proteopedia
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[[Image:1ce4.gif|left|200px]] | [[Image:1ce4.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_1ce4| PDB=1ce4 | SCENE= }} | |
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'''CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1''' | '''CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CE4 is a [[Single protein]] structure | + | 1CE4 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CE4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Fant, F.]] | [[Category: Fant, F.]] | ||
[[Category: Vranken, W F.]] | [[Category: Vranken, W F.]] | ||
| - | [[Category: | + | [[Category: Amphipathic helix]] |
| - | [[Category: | + | [[Category: Hiv infection]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:37:43 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:37, 2 May 2008
CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1
Overview
The disulfide bridge closed cyclic peptide corresponding to the whole Consensus V3 loop of the envelope protein gp120 of HIV-1 was examined by proton 2D-NMR spectroscopy in water and in a 20% trifluoroethanol/water solution. In water, NOE data support a beta-turn conformation for the central conservative GPGR region and point towards partial formation of a helix in the C-terminal part. Upon addition of trifluoroethanol, a C-terminal helix is formed. This is evidenced by NOE data, alpha-proton chemical shift changes and changes in the JN alpha vicinal coupling constants. The C-terminal helix is amphipathic and also occurs in other examined strains. It could therefore be an important feature for the functioning of the V3 loop.
About this Structure
1CE4 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
The complete Consensus V3 loop peptide of the envelope protein gp120 of HIV-1 shows pronounced helical character in solution., Vranken WF, Budesinsky M, Fant F, Boulez K, Borremans FA, FEBS Lett. 1995 Oct 23;374(1):117-21. PMID:7589496 Page seeded by OCA on Fri May 2 12:37:43 2008
