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O-GlcNAcase

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<StructureSection load='5m7t' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='5m7t' size='340' side='right' caption='Human OGA complex with PUGNAC type inhibitor (PDB code [[5m7t]]' scene=''>
== Function ==
== Function ==

Revision as of 06:29, 2 October 2020

Human OGA complex with PUGNAC type inhibitor (PDB code 5m7t

Drag the structure with the mouse to rotate

3D structures of O-GlcNAcase

Updated on 02-October-2020

References

  1. ↑ Shen DL, Gloster TM, Yuzwa SA, Vocadlo DJ. Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates. J Biol Chem. 2012 May 4;287(19):15395-408. doi: 10.1074/jbc.M111.310664. Epub, 2012 Feb 6. PMID:22311971 doi:http://dx.doi.org/10.1074/jbc.M111.310664
  2. ↑ Selnick HG, Hess JF, Tang C, Liu K, Schachter JB, Ballard JE, Marcus J, Klein DJ, Wang X, Pearson M, Savage MJ, Kaul R, Li TS, Vocadlo DJ, Zhou Y, Zhu Y, Mu C, Wang Y, Wei Z, Bai C, Duffy JL, McEachern EJ. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Nov 27;62(22):10062-10097. doi: 10.1021/acs.jmedchem.9b01090., Epub 2019 Sep 29. PMID:31487175 doi:http://dx.doi.org/10.1021/acs.jmedchem.9b01090

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