This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Pregnane X receptor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 24: Line 24:
**[[1ilh]], [[2qnv]] – hPXR LBD + ligand<br />
**[[1ilh]], [[2qnv]] – hPXR LBD + ligand<br />
-
**[[1m13]] – hPXR LBD + hyperforin<br />
+
**[[1m13]] – hPXR LBD + anti-angiogenic<br />
**[[1skx]] – hPXR LBD + antibiotic<br />
**[[1skx]] – hPXR LBD + antibiotic<br />
**[[3r8d]] – hPXR LBD + anti-HIV drug<br />
**[[3r8d]] – hPXR LBD + anti-HIV drug<br />
-
**[[1nrl]], [[2o9i]], [[5a86]], [[5x0r]] – hPXR LBD + nuclear receptor coactivator peptide + ligand<br />
+
**[[6hj2]] – hPXR LBD + cancer drug<br />
**[[4j5x]] – hPXR LBD + hRXR LBD + ligand<br />
**[[4j5x]] – hPXR LBD + hRXR LBD + ligand<br />
-
**[[3hvl]] – hPXR/steroid receptor coactivator + ligand<br />
+
**[[3hvl]], [[6xp9]], [[6nx1]], [[1nrl]], [[2o9i]], [[5a86]], [[5x0r]], [[6hty]] – hPXR/steroid receptor coactivator peptide + ligand<br />
-
**[[4ny9]] – hPXR LBD + antagonist<br />
+
**[[4s0s]], [[4xhd]] – hPXR LBD + adnectin derivative<br />
**[[4s0s]], [[4xhd]] – hPXR LBD + adnectin derivative<br />
**[[4s0t]] – hPXR LBD + adnectin-1 + inhibitor<br />
**[[4s0t]] – hPXR LBD + adnectin-1 + inhibitor<br />
**[[4x1f]], [[4x1g]] – hPXR LBD + estrogen derivative<br />
**[[4x1f]], [[4x1g]] – hPXR LBD + estrogen derivative<br />
**[[4xao]] – hPXR LBD + pesticide<br />
**[[4xao]] – hPXR LBD + pesticide<br />
-
**[[6s41]], [[6dup]] – hPXR LBD + inhibitor<br />
+
**[[6s41]], [[6dup]], [[6p2b]], [[4ny9]] – hPXR LBD + inhibitor<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:00, 7 October 2020

Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry 1skx)

Drag the structure with the mouse to rotate

3D structures of pregnane X receptor

Updated on 07-October-2020

References

  1. ↑ Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev. 2002 Oct;23(5):687-702. PMID:12372848 doi:http://dx.doi.org/10.1210/er.2001-0038
  2. ↑ Koutsounas I, Theocharis S, Patsouris E, Giaginis C. Pregnane X receptor (PXR) at the crossroads of human metabolism and disease. Curr Drug Metab. 2013 Mar;14(3):341-50. PMID:23237007
  3. ↑ Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol. 2005 May;19(5):1125-34. Epub 2005 Feb 10. PMID:15705662 doi:10.1210/me.2004-0346

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Pregnane_X_receptor"
Personal tools