3kin

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[[Image:3kin.png|left|200px]]
 
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==KINESIN (DIMERIC) FROM RATTUS NORVEGICUS==
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The line below this paragraph, containing "STRUCTURE_3kin", creates the "Structure Box" on the page.
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<StructureSection load='3kin' size='340' side='right'caption='[[3kin]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kin]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. The April 2005 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Kinesin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2005_4 10.2210/rcsb_pdb/mom_2005_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3KIN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3kin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kin OCA], [http://pdbe.org/3kin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kin RCSB], [http://www.ebi.ac.uk/pdbsum/3kin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kin ProSAT]</span></td></tr>
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{{STRUCTURE_3kin| PDB=3kin | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/3kin_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kin ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography. The two heads of the dimer are connected via a coiled-coil alpha-helical interaction of their necks. They are broadly similar to one another; differences are most apparent in the head-neck junction and in a moderate reorientation of the neck helices in order to adopt to the coiled-coil conformation. The heads show a rotational symmetry (approximately 120 degrees) about an axis close to that of the coiled-coil. This arrangement is unexpected since it is not compatible with the microtubule lattice. In this arrangement, the two heads of a kinesin dimer could not have equivalent interactions with microtubules.
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'''KINESIN (DIMERIC) FROM RATTUS NORVEGICUS'''
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The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.,Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E Cell. 1997 Dec 26;91(7):985-94. PMID:9428521<ref>PMID:9428521</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3kin" style="background-color:#fffaf0;"></div>
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{{ABSTRACT_9428521}}
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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==About this Structure==
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== References ==
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3KIN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 3KIN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIN OCA].
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Buffalo rat]]
[[Category: Kinesin]]
[[Category: Kinesin]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Biou, V.]]
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[[Category: Biou, V]]
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[[Category: Kozielski, F.]]
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[[Category: Kozielski, F]]
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[[Category: Mandelkow, E.]]
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[[Category: Mandelkow, E]]
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[[Category: Mandelkow, E M.]]
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[[Category: Mandelkow, E M]]
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[[Category: Marx, A.]]
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[[Category: Marx, A]]
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[[Category: Sack, S.]]
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[[Category: Sack, S]]
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[[Category: Schonbrunn, E.]]
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[[Category: Schonbrunn, E]]
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[[Category: Thompson, A.]]
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[[Category: Thompson, A]]
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[[Category: Thormahlen, M.]]
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[[Category: Thormahlen, M]]
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: Motor protein]]
[[Category: Motor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:27:13 2008''
 

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KINESIN (DIMERIC) FROM RATTUS NORVEGICUS

PDB ID 3kin

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