Galactokinase

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<StructureSection load='1wuu' size='340' side='right' caption='Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code [[1wuu]].' scene=''>
<StructureSection load='1wuu' size='340' side='right' caption='Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code [[1wuu]].' scene=''>
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__TOC__
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms numerous interactions with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK<ref>PMID:15590630</ref>.
==3D structures of galactokinase==
==3D structures of galactokinase==
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[[6gr2]] - hGK + ADP + gal - human<br />
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1wuu]] - hGK + Mg + AMPPNP + gal<br />
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[[6q3w]], [[6q8z]] - hGK + pyrazine derivative + gal<br />
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[[6gr2]] - hGALK + ADP + gal - human<br />
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[[6q91]] - hGK + benzamide derivative + gal<br />
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[[1wuu]] - hGALK + Mg + AMPPNP + gal<br />
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[[6q90]], [[6zgw]] - hGK + pyridine derivative + gal<br />
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[[6q3w]], [[6q8z]] - hGALK + pyrazine derivative + gal<br />
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[[6q3x]] - hGK + quinazoline derivative + gal<br />
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[[6q91]] - hGALK + benzamide derivative + gal<br />
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[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]] - hGK + pyrimidine derivative + gal<br />
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[[6q90]], [[6zgw]] - hGALK + pyridine derivative + gal<br />
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[[6qje]] - hGK + imidazole derivative + gal<br />
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[[6q3x]] - hGALK + quinazoline derivative + gal<br />
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[[2aj4]] - GK + Mg + AMPPNP + gal - yeast<br />
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[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]] - hGALK + pyrimidine derivative + gal<br />
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[[1s4e]] - GK + Mg + ADP + gal - ''Pyrococcus furiosus''<br />
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[[6qje]] - hGALK + imidazole derivative + gal<br />
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[[2dej]], [[2dei]] - GK + AMPPN derivative + gal - ''Pyrococcus horikoshii''<br />
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[[2aj4]] - GALK + Mg + AMPPNP + gal - yeast<br />
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[[1pie]] - GK + gal - ''Lactococcus lactis''<br />
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[[1s4e]] - GALK + Mg + ADP + gal - ''Pyrococcus furiosus''<br />
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[[6tep]] - BiGK + Mg + ADP - ''Bifidobacterium infantis''<br />
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[[2dej]], [[2dei]] - GALK + AMPPN derivative + gal - ''Pyrococcus horikoshii''<br />
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[[6ter]], [[6teq]] - BiGK + gal derivative<br />
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[[1pie]] - GALK + gal - ''Lactococcus lactis''<br />
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[[6tep]] - BiGALK + Mg + ADP - ''Bifidobacterium infantis''<br />
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[[6ter]], [[6teq]] - BiGALK + gal derivative<br />
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Revision as of 09:46, 12 October 2020

Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code 1wuu.

Drag the structure with the mouse to rotate

References

  1. ↑ Holden HM, Thoden JB, Timson DJ, Reece RJ. Galactokinase: structure, function and role in type II galactosemia. Cell Mol Life Sci. 2004 Oct;61(19-20):2471-84. doi: 10.1007/s00018-004-4160-6. PMID:15526155 doi:http://dx.doi.org/10.1007/s00018-004-4160-6
  2. ↑ Timson DJ, Reece RJ. Functional analysis of disease-causing mutations in human galactokinase. Eur J Biochem. 2003 Apr;270(8):1767-74. PMID:12694189
  3. ↑ Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactokinase: implications for type II galactosemia. J Biol Chem. 2005 Mar 11;280(10):9662-70. Epub 2004 Dec 7. PMID:15590630 doi:10.1074/jbc.M412916200

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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