This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2pwa
From Proteopedia
(Difference between revisions)
| (14 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2pwa.jpg|left|200px]]<br /><applet load="2pwa" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2pwa, resolution 0.83Å" /> | ||
| - | '''Crystal Structure of the complex of Proteinase K with Alanine Boronic acid at 0.83A resolution'''<br /> | ||
| - | == | + | ==Crystal Structure of the complex of Proteinase K with Alanine Boronic acid at 0.83A resolution== |
| - | + | <StructureSection load='2pwa' size='340' side='right'caption='[[2pwa]], [[Resolution|resolution]] 0.83Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2pwa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Engyodontium_album Engyodontium album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PWA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2PWA FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B2A:ALANINE+BORONIC+ACID'>B2A</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ic6|1ic6]], [[2pwb|2pwb]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidase_K Peptidase K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.64 3.4.21.64] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2pwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pwa OCA], [http://pdbe.org/2pwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pwa RCSB], [http://www.ebi.ac.uk/pdbsum/2pwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pwa ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRTK_TRIAL PRTK_TRIAL]] Hydrolyzes keratin at aromatic and hydrophobic residues. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pw/2pwa_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pwa ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Proteinase|Proteinase]] | ||
| + | *[[Proteinase 3D structures|Proteinase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Engyodontium album]] | [[Category: Engyodontium album]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Peptidase K]] | [[Category: Peptidase K]] | ||
| - | + | [[Category: Betzel, C]] | |
| - | [[Category: Betzel, C | + | [[Category: Jain, R]] |
| - | [[Category: Jain, R | + | [[Category: Kaur, P]] |
| - | [[Category: Kaur, P | + | [[Category: Perbandt, M]] |
| - | [[Category: Perbandt, M | + | [[Category: Sharma, S]] |
| - | [[Category: Sharma, S | + | [[Category: Singh, N]] |
| - | [[Category: Singh, N | + | [[Category: Singh, T P]] |
| - | [[Category: Singh, T | + | [[Category: Srinivasan, A]] |
| - | [[Category: Srinivasan, A | + | [[Category: Alanine boronic acid]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | + | [[Category: Proteinase k]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of the complex of Proteinase K with Alanine Boronic acid at 0.83A resolution
| |||||||||||
