This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Rab5 GDP/GTP exchange factor
From Proteopedia
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load='' size='350' side='right' caption='Human rabex-5 (cyan) complex with rabaptin (green and deeppink) and phosphate ion (PDB code [[4n3z]]).' scene=' | + | <StructureSection load='4n3z' size='350' side='right' caption='Human rabex-5 (cyan) complex with rabaptin (green and deeppink) and phosphate ion (PDB code [[4n3z]]).' scene=''> |
== Function == | == Function == | ||
| Line 6: | Line 6: | ||
== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='68/680139/Cv/ | + | The <scene name='68/680139/Cv/4'>rabapin helix packs against the Rasbex5</scene> forming a 3-helix bundle<ref>PMID:9323142</ref>. |
</StructureSection> | </StructureSection> | ||
| Line 18: | Line 18: | ||
[[2c7m]], [[2c7n]] – hRabex5 ubiquitin interacting motif + ubiquitin <br /> | [[2c7m]], [[2c7n]] – hRabex5 ubiquitin interacting motif + ubiquitin <br /> | ||
[[2ot3]] – hRabex5 Vps9 domain + Ras-related protein Rab21<br /> | [[2ot3]] – hRabex5 Vps9 domain + Ras-related protein Rab21<br /> | ||
| - | [[4n3x]] – hRabex5 CC domain + Rabaptin<br /> | ||
[[4n3z]] – hRabex5 5δ + Rabaptin<br /> | [[4n3z]] – hRabex5 5δ + Rabaptin<br /> | ||
[[4q9u]] – hRabex5 5δ (mutant) + Ras-related protein Rab5A<br /> | [[4q9u]] – hRabex5 5δ (mutant) + Ras-related protein Rab5A<br /> | ||
Current revision
| |||||||||||
3D Structures of Rab5 GDP/GTP exchange factor
Updated on 15-October-2020
1txu – hRabex5 Vps9 domain – human
4n3x – hRabex5 CC domain
2fid, 2fif – bRabex5 zinc finger and ubiquitin interacting motif + ubiquitin – bovine
2c7m, 2c7n – hRabex5 ubiquitin interacting motif + ubiquitin
2ot3 – hRabex5 Vps9 domain + Ras-related protein Rab21
4n3z – hRabex5 5δ + Rabaptin
4q9u – hRabex5 5δ (mutant) + Ras-related protein Rab5A
4n3y – hRabex5 5CC domain + Rab GTPase-binding effector protein
References
- ↑ Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142
- ↑ Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
