Galactokinase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='1wuu' size=' | + | <StructureSection load='1wuu' size='400' side='right' caption='Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code [[1wuu]].' scene='86/864099/Cv/1'> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
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The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in <scene name='86/864099/Cv/6'>particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK</scene><ref>PMID:15590630</ref>. | The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms <scene name='86/864099/Cv/5'>numerous interactions</scene> with GALK termini residues and in <scene name='86/864099/Cv/6'>particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK</scene><ref>PMID:15590630</ref>. | ||
*<scene name='86/864099/Cv/7'>Mg coordination site</scene>. | *<scene name='86/864099/Cv/7'>Mg coordination site</scene>. | ||
| + | *<scene name='86/864099/Cv/9'>AMPPNP binding site</scene>. | ||
| + | *<scene name='86/864099/Cv/10'>TextToBeDisplayed</scene>. | ||
==3D structures of galactokinase== | ==3D structures of galactokinase== | ||
Revision as of 13:55, 15 October 2020
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References
- ↑ Holden HM, Thoden JB, Timson DJ, Reece RJ. Galactokinase: structure, function and role in type II galactosemia. Cell Mol Life Sci. 2004 Oct;61(19-20):2471-84. doi: 10.1007/s00018-004-4160-6. PMID:15526155 doi:http://dx.doi.org/10.1007/s00018-004-4160-6
- ↑ Timson DJ, Reece RJ. Functional analysis of disease-causing mutations in human galactokinase. Eur J Biochem. 2003 Apr;270(8):1767-74. PMID:12694189
- ↑ Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactokinase: implications for type II galactosemia. J Biol Chem. 2005 Mar 11;280(10):9662-70. Epub 2004 Dec 7. PMID:15590630 doi:10.1074/jbc.M412916200
