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3ngg

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[[Image:3ngg.png|left|200px]]
 
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==X-ray Structure of Omwaprin==
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The line below this paragraph, containing "STRUCTURE_3ngg", creates the "Structure Box" on the page.
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<StructureSection load='3ngg' size='340' side='right'caption='[[3ngg]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ngg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3NGG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ngg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngg OCA], [http://pdbe.org/3ngg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ngg RCSB], [http://www.ebi.ac.uk/pdbsum/3ngg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngg ProSAT]</span></td></tr>
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-->
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</table>
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{{STRUCTURE_3ngg| PDB=3ngg | SCENE= }}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 50-residue snake venom protein L-omwaprin and its enantiomer D-omwaprin were prepared by total chemical synthesis. Radial diffusion assays were performed against Bacillus megaterium and Bacillus anthracis; both L-omwaprin and D-omwaprin showed anti-bacterial activity against B. megaterium. The native protein enantiomer, made of L- amino acids, failed to crystallize readily. However, when a racemic mixture containing equal amounts of L-omwaprin and D-omwaprin was used, diffraction quality crystals were obtained. The racemic protein sample crystallized in the centrosymmetric space group P2(1)/c and its structure was determined at atomic resolution (1.33 A) by a combination of Patterson and direct methods based on the strong scattering from the sulfur atoms in the eight cysteine residues per protein. Racemic crystallography once again proved to be a valuable method for obtaining crystals of recalcitrant proteins, and for determining high resolution X-ray structures by direct methods.
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===X-ray Structure of Omwaprin===
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Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography.,Banigan JR, Mandal K, Sawaya MR, Thammavongsa V, Hendrickx AP, Schneewind O, Yeates TO, H Kent SB Protein Sci. 2010 Jul 28. PMID:20669184<ref>PMID:20669184</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20669184}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3ngg" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20669184 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20669184}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3ngg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGG OCA].
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[[Category: Banigan, J R]]
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[[Category: Hendrickx, A P.A]]
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==Reference==
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[[Category: Kent, S B.H]]
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<ref group="xtra">PMID:20669184</ref><references group="xtra"/>
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[[Category: Mandal, K]]
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[[Category: Banigan, J R.]]
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[[Category: Sawaya, M R]]
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[[Category: Hendrickx, A P.A.]]
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[[Category: Schneewind, O]]
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[[Category: Kent, S B.H.]]
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[[Category: Thammavongsa, V]]
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[[Category: Mandal, K.]]
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[[Category: Yeates, T O]]
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[[Category: Sawaya, M R.]]
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[[Category: Antibiotic]]
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[[Category: Schneewind, O.]]
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[[Category: Direct method]]
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[[Category: Thammavongsa, V.]]
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[[Category: Racemic protein crystallography]]
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[[Category: Yeates, T O.]]
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[[Category: Venom protein]]

Current revision

X-ray Structure of Omwaprin

PDB ID 3ngg

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OCA

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