Fascin

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== Structural highlights ==
== Structural highlights ==
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FASC 3D structure shows it to contain 4 β-trefoil domains. A complex between FASC and an anti-metastatic agent shows the inhibitor binding to domains 1 and 2 <ref>PMID:30773430</ref>.
+
FASC 3D structure shows it to contain <scene name='86/862889/Cv/2'>4 β-trefoil domains</scene>. A complex between FASC and an anti-metastatic agent shows the inhibitor binding to domains 1 and 2 <ref>PMID:30773430</ref>.
</StructureSection>
</StructureSection>

Revision as of 14:45, 28 October 2020

Human fascin complex with anti-metastatic inhibitor (PDB id 6i0z).

Drag the structure with the mouse to rotate

3D structures of fascin

1dfc, 3llp, 3p53 - hFASC 1 - human
4gov, 4goy, 4gp0, 4gp3 - hFASC 1 (mutant)
6i0z, 6i17, 6i16, 6i18, 6i11, 6i10, 6i13, 6i12, 6i15, 6i14 - hFASC + anti-metastatic inhibitor
6b0t - hFASC + inhibitor

References

  1. ↑ Gungor-Ordueri NE, Cheng CY. Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics. Spermatogenesis. 2015 Feb 23;5(1):e1002733. doi: 10.1080/21565562.2014.1002733., eCollection 2015 Jan-Apr. PMID:26413410 doi:http://dx.doi.org/10.1080/21565562.2014.1002733
  2. ↑ Al-Alwan M, Olabi S, Ghebeh H, Barhoush E, Tulbah A, Al-Tweigeri T, Ajarim D, Adra C. Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules. PLoS One. 2011;6(11):e27339. doi: 10.1371/journal.pone.0027339. Epub 2011 Nov 4. PMID:22076152 doi:http://dx.doi.org/10.1371/journal.pone.0027339
  3. ↑ Qualtrough D, Smallwood K, Littlejohns D, Pignatelli M. The actin-bundling protein fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair. BMC Gastroenterol. 2011 Feb 23;11:14. doi: 10.1186/1471-230X-11-14. PMID:21345224 doi:http://dx.doi.org/10.1186/1471-230X-11-14
  4. ↑ Francis S, Croft D, Schuttelkopf AW, Parry C, Pugliese A, Cameron K, Claydon S, Drysdale M, Gardner C, Gohlke A, Goodwin G, Gray CH, Konczal J, McDonald L, Mezna M, Pannifer A, Paul NR, Machesky L, McKinnon H, Bower J. Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg Med Chem Lett. 2019 Jan 30. pii: S0960-894X(19)30056-3. doi:, 10.1016/j.bmcl.2019.01.035. PMID:30773430 doi:http://dx.doi.org/10.1016/j.bmcl.2019.01.035

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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