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1cx0

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[[Image:1cx0.gif|left|200px]]
[[Image:1cx0.gif|left|200px]]
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{{Structure
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|PDB= 1cx0 |SIZE=350|CAPTION= <scene name='initialview01'>1cx0</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1cx0", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1cx0| PDB=1cx0 | SCENE= }}
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|RELATEDENTRY=[[1drz|1DRZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cx0 OCA], [http://www.ebi.ac.uk/pdbsum/1cx0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cx0 RCSB]</span>
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'''HEPATITIS DELTA VIRUS RIBOZYME'''
'''HEPATITIS DELTA VIRUS RIBOZYME'''
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[[Category: Doudna, J A.]]
[[Category: Doudna, J A.]]
[[Category: Zhou, K.]]
[[Category: Zhou, K.]]
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[[Category: nested double pseudoknot rna structure]]
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[[Category: Nested double pseudoknot rna structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:12:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:30:17 2008''
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Revision as of 10:12, 2 May 2008

Image:1cx0.gif

Template:STRUCTURE 1cx0

HEPATITIS DELTA VIRUS RIBOZYME


Overview

The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.

About this Structure

1CX0 is a Single protein structure of sequence from Hepatitis delta virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:9783582 Page seeded by OCA on Fri May 2 13:12:18 2008

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